Expression of MS4A12 in cancer - Summary - The Human Protein Atlas

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MS4A12

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MS4A12
Gene description	Membrane-spanning 4-domains, subfamily A, member 12
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (colorectal cancer)
HPA (cell line):	Cell line enhanced (RH-30)
HPA (normal tissue):	Group enriched (colon, rectum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Luminal membranous expression in large intestine.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA057657
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (colorectal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA057657

GENE INFORMATION
Gene name	MS4A12 (HGNC Symbol)
Synonyms	FLJ20217, Ms4a10
Description	Membrane-spanning 4-domains, subfamily A, member 12 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	60492778 - 60507430
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000071203 (version 83.38)
Entrez gene	54860
UniProt	Q9NXJ0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NXJ0
Antibodypedia	MS4A12 antibodies

PROTEIN BROWSER

MS4A12-001	MS4A12-003	MS4A12-006	MS4A12-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MS4A12-001 ENSP00000016913 ENST00000016913	Q9NXJ0 [Direct mapping] Membrane-spanning 4-domains subfamily A member 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	267 aa 28.1 kDa	No	4
MS4A12-003 ENSP00000434783 ENST00000530007	E9PNI3 [Direct mapping] Membrane-spanning 4-domains subfamily A member 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	114 aa 12.1 kDa	No	1
MS4A12-006 ENSP00000431959 ENST00000526784	E9PIX5 [Direct mapping] Membrane-spanning 4-domains subfamily A member 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	174 aa 18.2 kDa	No	2
MS4A12-201 ENSP00000440424 ENST00000537076	Q9NXJ0 [Direct mapping] Membrane-spanning 4-domains subfamily A member 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	221 aa 23.2 kDa	No	2

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.