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RPS6KA2

GENERAL INFORMATION

Gene name

 RPS6KA2

Gene description

 Ribosomal protein S6 kinase, 90kDa, polypeptide 2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1, U-2197)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Approved based on 4 antibodies.
HPA045061 , HPA054237 , CAB026243 , CAB069428
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA045061
HPA054237
CAB026243
CAB069428

GENE INFORMATION

Gene name

 RPS6KA2 (HGNC Symbol)

Synonyms

 HU-2, RSK, RSK3

Description

 Ribosomal protein S6 kinase, 90kDa, polypeptide 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q27

Chromosome location (bp)

 166409364 - 166906451

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000071242 (version 83.38)

Entrez gene

 6196

UniProt

 Q15349 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15349

Antibodypedia

 RPS6KA2 antibodies

PROTEIN BROWSER
RPS6KA2-001
RPS6KA2-003
RPS6KA2-005
RPS6KA2-006
RPS6KA2-007
RPS6KA2-009
RPS6KA2-010
RPS6KA2-011
RPS6KA2-012
RPS6KA2-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPS6KA2-001
ENSP00000265678
ENST00000265678
Q15349 [Direct mapping]
Ribosomal protein S6 kinase alpha-2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008285 [negative regulation of cell proliferation]
GO:0031965 [nuclear membrane]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0045786 [negative regulation of cell cycle]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
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 733 aa
83.2 kDa 		No 0
RPS6KA2-003
ENSP00000427015
ENST00000503859
Q15349 [Direct mapping]
Ribosomal protein S6 kinase alpha-2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001556 [oocyte maturation]
GO:0002035 [brain renin-angiotensin system]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007507 [heart development]
GO:0008285 [negative regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010659 [cardiac muscle cell apoptotic process]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0031965 [nuclear membrane]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0045786 [negative regulation of cell cycle]
GO:0045835 [negative regulation of meiotic nuclear division]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0060047 [heart contraction]
GO:0070613 [regulation of protein processing]
GO:0071322 [cellular response to carbohydrate stimulus]
Show all
 741 aa
84 kDa 		No 0
RPS6KA2-005
ENSP00000422435
ENST00000510118
F2Z2J1 [Direct mapping]
Ribosomal protein S6 kinase
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0031965 [nuclear membrane]
GO:0035556 [intracellular signal transduction]
Show all
 758 aa
85.6 kDa 		No 0
RPS6KA2-006
ENSP00000422484
ENST00000481261
B7Z3B5 [Direct mapping]
Ribosomal protein S6 kinase alpha-2; Ribosomal protein S6 kinase, 90kDa, polypeptide 2, isoform CRA_a; cDNA FLJ55331, highly similar to Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005840 [ribosome]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0031965 [nuclear membrane]
GO:0035556 [intracellular signal transduction]
Show all
 644 aa
73.1 kDa 		No 0
RPS6KA2-007
ENSP00000386050
ENST00000405189
B7Z3B5 [Direct mapping]
Ribosomal protein S6 kinase alpha-2; Ribosomal protein S6 kinase, 90kDa, polypeptide 2, isoform CRA_a; cDNA FLJ55331, highly similar to Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005840 [ribosome]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0031965 [nuclear membrane]
GO:0035556 [intracellular signal transduction]
Show all
 644 aa
73.1 kDa 		No 0
RPS6KA2-009
ENSP00000425148
ENST00000506565
D6RE03 [Direct mapping]
Ribosomal protein S6 kinase alpha-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005524 [ATP binding]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
Show all
 171 aa
19.2 kDa 		No 0
RPS6KA2-010
ENSP00000427605
ENST00000512860
D6RHW7 [Direct mapping]
Ribosomal protein S6 kinase alpha-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005524 [ATP binding]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
Show all
 96 aa
11.3 kDa 		No 0
RPS6KA2-011
ENSP00000423114
ENST00000507371
D6RA62 [Direct mapping]
Ribosomal protein S6 kinase alpha-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005524 [ATP binding]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
Show all
 141 aa
16.4 kDa 		No 0
RPS6KA2-012
ENSP00000425458
ENST00000511034
D6RD75 [Direct mapping]
Ribosomal protein S6 kinase alpha-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
Show all
 36 aa
4.3 kDa 		No 0
RPS6KA2-013
ENSP00000422197
ENST00000507350
D6R910 [Direct mapping]
Ribosomal protein S6 kinase alpha-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005524 [ATP binding]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
Show all
 125 aa
14.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.