Cell atlas - LMCD1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	LMCD1
Gene description	LIM and cysteine-rich domains 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytoplasm & cell junctions.
RNA cell category	Cell line enhanced (U-2197)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Cytosol (supported)
Additional location	In addition localized to the Plasma membrane (approved), Cell Junctions (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA024059
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2197) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytoplasm & cell junctions.

Main location

Nucleus (supported), Cytosol (supported)

Additional location

Plasma membrane (approved), Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA024059	A-431	Plasma membrane
HPA024059	A-431	Cell Junctions
HPA024059	U-2 OS	Nucleus	Spatial
		Plasma membrane
		Cell Junctions
		Cytosol	Spatial
HPA024059	U-251 MG	Nucleus	Spatial
		Plasma membrane
		Cytosol	Spatial

GENE INFORMATION
Gene name	LMCD1
Synonyms
Description	LIM and cysteine-rich domains 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement in protein-protein interactions. The protein may act as a co-regulator of transcription along with other transcription factors. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Chromosome	3
Cytoband	p25.3
Chromosome location (bp)	8501707 - 8574673
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000071282 (version 83.38)
Entrez gene	29995
UniProt	Q9NZU5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZU5
Antibodypedia	LMCD1 antibodies

PROTEIN BROWSER

LMCD1-001	LMCD1-002	LMCD1-004	LMCD1-006	LMCD1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LMCD1-001 ENSP00000157600 ENST00000157600	Q9NZU5 [Direct mapping] LIM and cysteine-rich domains protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002230 [positive regulation of defense response to virus by host] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0010611 [regulation of cardiac muscle hypertrophy] GO:0031012 [extracellular matrix] GO:0044267 [cellular protein metabolic process] GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	365 aa 40.8 kDa	No	0
LMCD1-002 ENSP00000396515 ENST00000454244	Q9NZU5 [Direct mapping] LIM and cysteine-rich domains protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0003714 [transcription corepressor activity] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0010611 [regulation of cardiac muscle hypertrophy] GO:0031012 [extracellular matrix] GO:0044267 [cellular protein metabolic process] GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	292 aa 32.9 kDa	No	0
LMCD1-004 ENSP00000400555 ENST00000415597	C9IYS1 [Direct mapping] LIM and cysteine-rich domains protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	234 aa 26.2 kDa	No	0
LMCD1-006 ENSP00000411222 ENST00000426878	H7C3D2 [Direct mapping] LIM and cysteine-rich domains protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	247 aa 27.4 kDa	No	0
LMCD1-201 ENSP00000380542 ENST00000397386	B4DEY6 [Direct mapping] LIM and cysteine-rich domains protein 1; cDNA FLJ52480, highly similar to LIM and cysteine-rich domains protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	253 aa 28.5 kDa	No	0