Expression of TRIP13 in cancer - Summary - The Human Protein Atlas

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TRIP13

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TRIP13
Gene description	Thyroid hormone receptor interactor 13
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA005727 , HPA053093
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), ovarian cancer (favourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Ovarian cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA005727	HPA053093

GENE INFORMATION
Gene name	TRIP13 (HGNC Symbol)
Synonyms	16E1BP
Description	Thyroid hormone receptor interactor 13 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]
Chromosome	5
Cytoband	p15.33
Chromosome location (bp)	892643 - 919357
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000071539 (version 83.38)
Entrez gene	9319
UniProt	Q15645 (UniProt - Evidence at protein level)
neXtProt	NX_Q15645
Antibodypedia	TRIP13 antibodies

PROTEIN BROWSER

TRIP13-001	TRIP13-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRIP13-001 ENSP00000166345 ENST00000166345	Q15645 [Direct mapping] Pachytene checkpoint protein 2 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001556 [oocyte maturation] GO:0001673 [male germ cell nucleus] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006302 [double-strand break repair] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007130 [synaptonemal complex assembly] GO:0007131 [reciprocal meiotic recombination] GO:0007141 [male meiosis I] GO:0007144 [female meiosis I] GO:0007283 [spermatogenesis] GO:0007286 [spermatid development] GO:0042802 [identical protein binding] GO:0048477 [oogenesis] GO:1903506 [regulation of nucleic acid-templated transcription] Show all	432 aa 48.6 kDa	No	0
TRIP13-006 ENSP00000427528 ENST00000513435	H0YAL2 [Direct mapping] Pachytene checkpoint protein 2 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] Show all	249 aa 28.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.