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TCF3

GENERAL INFORMATION

Gene name

 TCF3

Gene description

 Transcription factor 3

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA049808 , HPA062476 , CAB018351
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA049808
HPA062476
CAB018351

GENE INFORMATION

Gene name

 TCF3 (HGNC Symbol)

Synonyms

 bHLHb21, E2A, E47, ITF1, MGC129647, MGC129648, VDIR

Description

 Transcription factor 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 1609290 - 1652605

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000071564 (version 83.38)

Entrez gene

 6929

UniProt

 P15923 (UniProt - Evidence at protein level)

neXtProt

 NX_P15923

Antibodypedia

 TCF3 antibodies

PROTEIN BROWSER
«
TCF3-001
TCF3-002
TCF3-003
TCF3-004
TCF3-005
TCF3-006
TCF3-007
TCF3-008
TCF3-009
TCF3-013
TCF3-014
TCF3-016
TCF3-017
TCF3-201
TCF3-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TCF3-001
ENSP00000480564
ENST00000611869
P15923 [Direct mapping]
Transcription factor E2-alpha
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002326 [B cell lineage commitment]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0030183 [B cell differentiation]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0033152 [immunoglobulin V(D)J recombination]
GO:0035326 [enhancer binding]
GO:0042692 [muscle cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043234 [protein complex]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070644 [vitamin D response element binding]
GO:0070888 [E-box binding]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
Show all
 654 aa
67.6 kDa 		No 0
TCF3-002
ENSP00000468487
ENST00000588136
P15923 [Direct mapping]
Transcription factor E2-alpha
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002326 [B cell lineage commitment]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0030183 [B cell differentiation]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0033152 [immunoglobulin V(D)J recombination]
GO:0035326 [enhancer binding]
GO:0042692 [muscle cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043234 [protein complex]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070644 [vitamin D response element binding]
GO:0070888 [E-box binding]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
Show all
 651 aa
67.3 kDa 		No 0
TCF3-003
ENSP00000378813
ENST00000395423
P15923 [Direct mapping]
Transcription factor E2-alpha
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002326 [B cell lineage commitment]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0030183 [B cell differentiation]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0033152 [immunoglobulin V(D)J recombination]
GO:0035326 [enhancer binding]
GO:0042692 [muscle cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043234 [protein complex]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070644 [vitamin D response element binding]
GO:0070888 [E-box binding]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
Show all
 658 aa
68.5 kDa 		No 0
TCF3-004
ENSP00000466565
ENST00000590684
K7EMM4 [Direct mapping]
Transcription factor E2-alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0045666 [positive regulation of neuron differentiation]
GO:0046983 [protein dimerization activity]
Show all
 220 aa
24 kDa 		No 0
TCF3-005
ENSP00000465510
ENST00000585731
A0A0A0MTS0 [Direct mapping]
Transcription factor E2-alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0045666 [positive regulation of neuron differentiation]
GO:0046983 [protein dimerization activity]
Show all
 159 aa
18.1 kDa 		No 0
TCF3-006
ENSP00000465549
ENST00000592628
K7EKB9 [Direct mapping]
Transcription factor E2-alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0045666 [positive regulation of neuron differentiation]
GO:0046983 [protein dimerization activity]
Show all
 179 aa
20.1 kDa 		No 0
TCF3-007
ENSP00000466954
ENST00000586318
K7ENI0 [Direct mapping]
Transcription factor E2-alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0045666 [positive regulation of neuron differentiation]
Show all
 95 aa
10 kDa 		No 0
TCF3-008
ENSP00000396363
ENST00000453954
X6REB3 [Direct mapping]
Transcription factor E2-alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0045666 [positive regulation of neuron differentiation]
GO:0046983 [protein dimerization activity]
Show all
 679 aa
70.1 kDa 		No 0
TCF3-009
ENSP00000466952
ENST00000590436
K7ENH8 [Direct mapping]
Transcription factor E2-alpha
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0045666 [positive regulation of neuron differentiation]
GO:0046983 [protein dimerization activity]
Show all
 314 aa
33.5 kDa 		No 0
TCF3-013
ENSP00000467508
ENST00000587425
K7EPS2 [Direct mapping]
Transcription factor E2-alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0045666 [positive regulation of neuron differentiation]
GO:0046983 [protein dimerization activity]
Show all
 165 aa
18.7 kDa 		No 0
TCF3-014
ENSP00000468481
ENST00000593064
K7ERZ7 [Direct mapping]
Transcription factor E2-alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0045666 [positive regulation of neuron differentiation]
GO:0046983 [protein dimerization activity]
Show all
 204 aa
22.5 kDa 		No 0
TCF3-016
ENSP00000467388
ENST00000586410
K7EPH6 [Direct mapping]
Transcription factor E2-alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0045666 [positive regulation of neuron differentiation]
Show all
 96 aa
9.6 kDa 		No 0
TCF3-017
ENSP00000466052
ENST00000587235
K7ELF3 [Direct mapping]
Transcription factor E2-alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0045666 [positive regulation of neuron differentiation]
Show all
 213 aa
21.9 kDa 		No 0
TCF3-201
ENSP00000262965
ENST00000262965
P15923 [Direct mapping]
Transcription factor E2-alpha
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000788 [nuclear nucleosome]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001779 [natural killer cell differentiation]
GO:0002326 [B cell lineage commitment]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0010628 [positive regulation of gene expression]
GO:0030098 [lymphocyte differentiation]
GO:0030183 [B cell differentiation]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0032496 [response to lipopolysaccharide]
GO:0033077 [T cell differentiation in thymus]
GO:0033152 [immunoglobulin V(D)J recombination]
GO:0035326 [enhancer binding]
GO:0042493 [response to drug]
GO:0042692 [muscle cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0043234 [protein complex]
GO:0043425 [bHLH transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0043966 [histone H3 acetylation]
GO:0043967 [histone H4 acetylation]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048468 [cell development]
GO:0048541 [Peyer's patch development]
GO:0050821 [protein stabilization]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070644 [vitamin D response element binding]
GO:0070888 [E-box binding]
GO:0090575 [RNA polymerase II transcription factor complex]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
Show all
 654 aa
67.6 kDa 		No 0
TCF3-202
ENSP00000344375
ENST00000344749
A0A0A0MRB7 [Direct mapping]
Transcription factor E2-alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0045666 [positive regulation of neuron differentiation]
GO:0046983 [protein dimerization activity]
Show all
 600 aa
62 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.