Cell atlas - TRIB2 - The Human Protein Atlas

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TRIB2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TRIB2
Gene description	Tribbles pseudokinase 2
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Cell line enhanced (WM-115, K-562)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA001305
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (WM-115, K-562) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001305	A-431	Nucleoplasm
	HPA001305	A-431	Cytosol
	HPA001305	U-2 OS	Nucleoplasm
	HPA001305	U-2 OS	Cytosol
	HPA001305	U-251 MG	Nucleoplasm
	HPA001305	U-251 MG	Cytosol

GENE INFORMATION
Gene name	TRIB2 (HGNC Symbol)
Synonyms	GS3955, TRB2
Description	Tribbles pseudokinase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Chromosome	2
Cytoband	p24.3
Chromosome location (bp)	12716889 - 12742734
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000071575 (version 83.38)
Entrez gene	28951
UniProt	Q92519 (UniProt - Evidence at transcript level)
neXtProt	NX_Q92519
Antibodypedia	TRIB2 antibodies

PROTEIN BROWSER

TRIB2-001	TRIB2-002	TRIB2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRIB2-001 ENSP00000155926 ENST00000155926	Q92519 [Direct mapping] Tribbles homolog 2 Show all	Enzymes Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004672 [protein kinase activity] GO:0004860 [protein kinase inhibitor activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0008134 [transcription factor binding] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0031625 [ubiquitin protein ligase binding] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0043405 [regulation of MAP kinase activity] GO:0045081 [negative regulation of interleukin-10 biosynthetic process] GO:0045599 [negative regulation of fat cell differentiation] GO:0055106 [ubiquitin-protein transferase regulator activity] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] Show all	343 aa 38.8 kDa	No	1
TRIB2-002 ENSP00000370874 ENST00000381465	F8WA18 [Direct mapping] Tribbles homolog 2; cDNA FLJ57420 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0043405 [regulation of MAP kinase activity] Show all	207 aa 23.6 kDa	No	1
TRIB2-004 ENSP00000384260 ENST00000405331	B5MCX4 [Direct mapping] Tribbles homolog 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0043405 [regulation of MAP kinase activity] Show all	252 aa 28.5 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.