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DAZAP1

GENERAL INFORMATION

Gene name

 DAZAP1

Gene description

 DAZ associated protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA004201 , HPA004631
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004201
HPA004631

GENE INFORMATION

Gene name

 DAZAP1 (HGNC Symbol)

Synonyms

 MGC19907

Description

 DAZ associated protein 1 (HGNC Symbol)

Entrez gene summary

 In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 1407569 - 1435687

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000071626 (version 83.38)

Entrez gene

 26528

UniProt

 Q96EP5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96EP5

Antibodypedia

 DAZAP1 antibodies

PROTEIN BROWSER
DAZAP1-001
DAZAP1-003
DAZAP1-006
DAZAP1-010
DAZAP1-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DAZAP1-001
ENSP00000233078
ENST00000233078
Q96EP5 [Direct mapping]
DAZ-associated protein 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0001893 [maternal placenta development]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007283 [spermatogenesis]
GO:0008283 [cell proliferation]
GO:0030154 [cell differentiation]
GO:0035613 [RNA stem-loop binding]
GO:0044822 [poly(A) RNA binding]
GO:0048026 [positive regulation of mRNA splicing, via spliceosome]
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 407 aa
43.4 kDa 		No 0
DAZAP1-003
ENSP00000337132
ENST00000336761
Q96EP5 [Direct mapping]
DAZ-associated protein 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0030154 [cell differentiation]
GO:0044822 [poly(A) RNA binding]
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 378 aa
40.5 kDa 		No 0
DAZAP1-006
ENSP00000467680
ENST00000592522
K7EQ55 [Direct mapping]
DAZ-associated protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 406 aa
43.3 kDa 		No 0
DAZAP1-010
ENSP00000465433
ENST00000587079
K7EK33 [Direct mapping]
DAZ-associated protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 406 aa
43.3 kDa 		No 0
DAZAP1-011
ENSP00000467613
ENST00000592453
K7EQ02 [Direct mapping]
DAZ-associated protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
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 327 aa
35 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.