Expression of FAM50A in cancer - Summary - The Human Protein Atlas

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FAM50A

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM50A
Gene description	Family with sequence similarity 50, member A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA003585
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), colorectal cancer (unfavourable) and cervical cancer (favourable).
Liver cancer p<0.001 Colorectal cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003585

GENE INFORMATION
Gene name	FAM50A (HGNC Symbol)
Synonyms	9F, DXS9928E, HXC-26, XAP5
Description	Family with sequence similarity 50, member A (HGNC Symbol)
Entrez gene summary	This gene belongs to the FAM50 family. The encoded protein is highly conserved in length and sequence across different species. It is a basic protein containing a nuclear localization signal, and may function as a DNA-binding protein or a transcriptional factor. [provided by RefSeq, Sep 2009]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	154444126 - 154450654
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000071859 (version 83.38)
Entrez gene	9130
UniProt	Q14320 (UniProt - Evidence at protein level)
neXtProt	NX_Q14320
Antibodypedia	FAM50A antibodies

PROTEIN BROWSER

FAM50A-001	FAM50A-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM50A-001 ENSP00000377225 ENST00000393600	Q14320 [Direct mapping] Protein FAM50A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0007283 [spermatogenesis] GO:0044822 [poly(A) RNA binding] Show all	339 aa 40.2 kDa	No	0
FAM50A-002 ENSP00000158526 ENST00000158526	B0S8I6 [Direct mapping] Protein FAM50A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] Show all	260 aa 30.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.