Expression of FAM3A in cancer - Summary - The Human Protein Atlas

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FAM3A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM3A
Gene description	Family with sequence similarity 3, member A
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Extracellular positivity and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. CAB025016
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB025016

GENE INFORMATION
Gene name	FAM3A (HGNC Symbol)
Synonyms	2-19, DXS560S, XAP-7
Description	Family with sequence similarity 3, member A (HGNC Symbol)
Entrez gene summary	This gene encodes a cytokine-like protein. The expression of this gene may be regulated by peroxisome proliferator-activated receptor gamma, and the encoded protein may be involved in the regulation of glucose and lipid metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	154506159 - 154516242
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000071889 (version 83.38)
Entrez gene	60343
UniProt	P98173 (UniProt - Evidence at protein level)
neXtProt	NX_P98173
Antibodypedia	FAM3A antibodies

PROTEIN BROWSER

FAM3A-001	FAM3A-003	FAM3A-004	FAM3A-012	FAM3A-017	FAM3A-018	FAM3A-020	FAM3A-201	FAM3A-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM3A-001 ENSP00000352955 ENST00000359889	P98173 [Direct mapping] Protein FAM3A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0008150 [biological_process] Show all	230 aa 25.2 kDa	No	1
FAM3A-003 ENSP00000358657 ENST00000369643	P98173 [Direct mapping] Protein FAM3A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0008150 [biological_process] Show all	230 aa 25.2 kDa	No	1
FAM3A-004 ENSP00000416146 ENST00000447601	P98173 [Direct mapping] Protein FAM3A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0008150 [biological_process] Show all	230 aa 25.2 kDa	No	1
FAM3A-012 ENSP00000358655 ENST00000369641	Q5HY75 [Direct mapping] Protein FAM3A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	237 aa 25.8 kDa	No	1
FAM3A-017 ENSP00000377202 ENST00000393572	P98173 [Direct mapping] Protein FAM3A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0008150 [biological_process] Show all	192 aa 21.2 kDa	No	0
FAM3A-018 ENSP00000408973 ENST00000442929	A6QRH8 [Direct mapping] Protein FAM3A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		21 aa 2.3 kDa	No	0
FAM3A-020 ENSP00000396845 ENST00000426266	A6QRH7 [Direct mapping] Protein FAM3A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	163 aa 17.4 kDa	No	1
FAM3A-201 ENSP00000320521 ENST00000322269	D3DWX8 [Direct mapping] Family with sequence similarity 3, member A, isoform CRA_c; Protein FAM3A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		244 aa 26.7 kDa	No	0
FAM3A-202 ENSP00000393086 ENST00000419205	P98173 [Direct mapping] Protein FAM3A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0008150 [biological_process] Show all	213 aa 23.4 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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