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MYO3B

GENERAL INFORMATION

Gene name

 MYO3B

Gene description

 Myosin IIIB

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (HDLM-2, HEL, RT4)
HPA (normal tissue):Group enriched (epididymis, kidney, parathyroid gland, urinary bladder)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA015745 , HPA045483
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA015745
HPA045483

GENE INFORMATION

Gene name

 MYO3B

Synonyms

Description

 Myosin IIIB (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 170178145 - 170655171

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000071909 (version 83.38)

Entrez gene

 140469

UniProt

 Q8WXR4 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8WXR4

Antibodypedia

 MYO3B antibodies

PROTEIN BROWSER
MYO3B-001
MYO3B-004
MYO3B-005
MYO3B-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYO3B-001
ENSP00000386497
ENST00000409044
Q8WXR4 [Direct mapping]
Myosin-IIIb
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007601 [visual perception]
GO:0016459 [myosin complex]
GO:0050896 [response to stimulus]
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 1314 aa
148.6 kDa 		No 0
MYO3B-004
ENSP00000386213
ENST00000408978
Q8WXR4 [Direct mapping]
Myosin-IIIb
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000146 [microfilament motor activity]
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007601 [visual perception]
GO:0016459 [myosin complex]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0032426 [stereocilium bundle tip]
GO:0032433 [filopodium tip]
GO:0046777 [protein autophosphorylation]
GO:0050896 [response to stimulus]
GO:0051491 [positive regulation of filopodium assembly]
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 1341 aa
151.8 kDa 		No 0
MYO3B-005
ENSP00000446237
ENST00000484338
F5H2J1 [Direct mapping]
Myosin-IIIb
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   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0003774 [motor activity]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016459 [myosin complex]
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 1105 aa
126.1 kDa 		No 0
MYO3B-007
ENSP00000401160
ENST00000442690
H7C1M9 [Direct mapping]
Myosin-IIIb
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 360 aa
41 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.