Expression of CYBRD1 in cancer - Summary - The Human Protein Atlas

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CYBRD1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CYBRD1
Gene description	Cytochrome b reductase 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, BJ hTERT+)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General membranous and cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA014757
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014757

GENE INFORMATION
Gene name	CYBRD1 (HGNC Symbol)
Synonyms	CYB561A2, DCYTB, FLJ23462, FRRS3
Description	Cytochrome b reductase 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	171522247 - 171558133
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000071967 (version 83.38)
Entrez gene	79901
UniProt	Q53TN4 (UniProt - Evidence at protein level)
neXtProt	NX_Q53TN4
Antibodypedia	CYBRD1 antibodies

PROTEIN BROWSER

CYBRD1-001	CYBRD1-002	CYBRD1-003	CYBRD1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYBRD1-001 ENSP00000319141 ENST00000321348	Q53TN4 [Direct mapping] Cytochrome b reductase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000293 [ferric-chelate reductase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006879 [cellular iron ion homeostasis] GO:0010039 [response to iron ion] GO:0016021 [integral component of membrane] GO:0016722 [oxidoreductase activity, oxidizing metal ions] GO:0031526 [brush border membrane] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	286 aa 31.6 kDa	No	6
CYBRD1-002 ENSP00000386739 ENST00000409484	Q53TN4 [Direct mapping] Cytochrome b reductase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000293 [ferric-chelate reductase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006879 [cellular iron ion homeostasis] GO:0016021 [integral component of membrane] GO:0016722 [oxidoreductase activity, oxidizing metal ions] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	228 aa 25.1 kDa	No	4
CYBRD1-003 ENSP00000364401 ENST00000375252	Q53TN4 [Direct mapping] Cytochrome b reductase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000293 [ferric-chelate reductase activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006879 [cellular iron ion homeostasis] GO:0016021 [integral component of membrane] GO:0016722 [oxidoreductase activity, oxidizing metal ions] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	157 aa 17.9 kDa	No	2
CYBRD1-007 ENSP00000402242 ENST00000445146	C9JML1 [Direct mapping] Cytochrome b reductase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055114 [oxidation-reduction process] Show all	175 aa 19.3 kDa	No	5

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.