Expression of SLC6A15 in cancer - Summary

GENERAL INFORMATION
Gene name	SLC6A15
Gene description	Solute carrier family 6 (neutral amino acid transporter), member 15
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (melanoma)
HPA (cell line):	Cell line enhanced (SCLC-21H, SK-MEL-30)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several different tissue types, including subsets of neurons.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA008609
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (melanoma)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA008609

GENE INFORMATION
Gene name	SLC6A15 (HGNC Symbol)
Synonyms	FLJ10316, hv7-3, NTT73, SBAT1, V7-3
Description	Solute carrier family 6 (neutral amino acid transporter), member 15 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Chromosome	12
Cytoband	q21.31
Chromosome location (bp)	84859488 - 84913615
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072041 (version 83.38)
Entrez gene	55117
UniProt	Q9H2J7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H2J7
Antibodypedia	SLC6A15 antibodies

PROTEIN BROWSER

SLC6A15-001	SLC6A15-002	SLC6A15-003	SLC6A15-004	SLC6A15-007	SLC6A15-010	SLC6A15-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC6A15-001 ENSP00000266682 ENST00000266682	Q9H2J7 [Direct mapping] Sodium-dependent neutral amino acid transporter B(0)AT2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005298 [proline:sodium symporter activity] GO:0005326 [neurotransmitter transporter activity] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006836 [neurotransmitter transport] GO:0006865 [amino acid transport] GO:0015804 [neutral amino acid transport] GO:0015820 [leucine transport] GO:0015824 [proline transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	730 aa 81.8 kDa	No	>9
SLC6A15-002 ENSP00000390706 ENST00000450363	Q9H2J7 [Direct mapping] Sodium-dependent neutral amino acid transporter B(0)AT2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005298 [proline:sodium symporter activity] GO:0005326 [neurotransmitter transporter activity] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006836 [neurotransmitter transport] GO:0006865 [amino acid transport] GO:0015804 [neutral amino acid transport] GO:0015820 [leucine transport] GO:0015824 [proline transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	289 aa 32.3 kDa	No	5
SLC6A15-003 ENSP00000450145 ENST00000552192	Q9H2J7 [Direct mapping] Sodium-dependent neutral amino acid transporter B(0)AT2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005298 [proline:sodium symporter activity] GO:0005326 [neurotransmitter transporter activity] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006836 [neurotransmitter transport] GO:0006865 [amino acid transport] GO:0015804 [neutral amino acid transport] GO:0015820 [leucine transport] GO:0015824 [proline transport] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	623 aa 69.9 kDa	No	>9
SLC6A15-004 ENSP00000311645 ENST00000309283	F8WJN6 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	316 aa 35.6 kDa	No	6
SLC6A15-007 ENSP00000449263 ENST00000551612	F8VX16 [Direct mapping] Sodium-dependent neutral amino acid transporter B(0)AT2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	72 aa 8.1 kDa	No	2
SLC6A15-010 ENSP00000448308 ENST00000549540	F8VSG1 [Direct mapping] Sodium-dependent neutral amino acid transporter B(0)AT2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	96 aa 10.7 kDa	No	0
SLC6A15-011 ENSP00000475035 ENST00000551010	S4R439 [Direct mapping] Sodium-dependent neutral amino acid transporter B(0)AT2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		20 aa 2.3 kDa	No	0