Expression of RDH11 in cancer - Summary - The Human Protein Atlas

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RDH11

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RDH11
Gene description	Retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (prostate cancer)
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enriched (prostate)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in prostate.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB046011
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), head and neck cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB046011

GENE INFORMATION
Gene name	RDH11 (HGNC Symbol)
Synonyms	ARSDR1, MDT1, SDR7C1
Description	Retinol dehydrogenase 11 (all-trans/9-cis/11-cis) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. [provided by RefSeq, Nov 2011]
Chromosome	14
Cytoband	q24.1
Chromosome location (bp)	67676801 - 67695814
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072042 (version 83.38)
Entrez gene	51109
UniProt	Q8TC12 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TC12
Antibodypedia	RDH11 antibodies

PROTEIN BROWSER

RDH11-001	RDH11-003	RDH11-004	RDH11-010	RDH11-011	RDH11-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RDH11-001 ENSP00000370750 ENST00000381346	Q8TC12 [Direct mapping] Retinol dehydrogenase 11 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0001917 [photoreceptor inner segment] GO:0004745 [retinol dehydrogenase activity] GO:0005622 [intracellular] GO:0005789 [endoplasmic reticulum membrane] GO:0007603 [phototransduction, visible light] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016062 [adaptation of rhodopsin mediated signaling] GO:0016491 [oxidoreductase activity] GO:0042572 [retinol metabolic process] GO:0042574 [retinal metabolic process] GO:0052650 [NADP-retinol dehydrogenase activity] GO:0055114 [oxidation-reduction process] Show all	318 aa 35.4 kDa	Yes	0
RDH11-003 ENSP00000452079 ENST00000553384	Q8TC12 [Direct mapping] Retinol dehydrogenase 11 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0004745 [retinol dehydrogenase activity] GO:0005622 [intracellular] GO:0005789 [endoplasmic reticulum membrane] GO:0007603 [phototransduction, visible light] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0042572 [retinol metabolic process] GO:0042574 [retinal metabolic process] GO:0052650 [NADP-retinol dehydrogenase activity] GO:0055114 [oxidation-reduction process] Show all	305 aa 34 kDa	Yes	0
RDH11-004 ENSP00000416395 ENST00000428130	Q8TC12 [Direct mapping] Retinol dehydrogenase 11 Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0004745 [retinol dehydrogenase activity] GO:0005622 [intracellular] GO:0005789 [endoplasmic reticulum membrane] GO:0007603 [phototransduction, visible light] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0042572 [retinol metabolic process] GO:0042574 [retinal metabolic process] GO:0052650 [NADP-retinol dehydrogenase activity] GO:0055114 [oxidation-reduction process] Show all	248 aa 27.4 kDa	Yes	0
RDH11-010 ENSP00000450435 ENST00000557726	G3V234 [Direct mapping] Retinol dehydrogenase 11 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	187 aa 20.6 kDa	Yes	0
RDH11-011 ENSP00000450651 ENST00000557273	G3V2G6 [Direct mapping] Retinol dehydrogenase 11 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	178 aa 20 kDa	Yes	0
RDH11-013 ENSP00000450802 ENST00000554035	H0YJ46 [Direct mapping] Retinol dehydrogenase 11 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	204 aa 23.2 kDa	No	0

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