Expression of SPP2 in cancer - Summary - The Human Protein Atlas

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SPP2

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	SPP2
Gene description	Secreted phosphoprotein 2, 24kDa
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	SPP2 (HGNC Symbol)
Synonyms	SPP24
Description	Secreted phosphoprotein 2, 24kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily. [provided by RefSeq, Oct 2008]
Chromosome	2
Cytoband	q37.1
Chromosome location (bp)	234050679 - 234077134
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072080 (version 83.38)
Entrez gene	6694
UniProt	Q13103 (UniProt - Evidence at protein level)
neXtProt	NX_Q13103
Antibodypedia	SPP2 antibodies

PROTEIN BROWSER

SPP2-001	SPP2-002	SPP2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPP2-001 ENSP00000168148 ENST00000168148	Q13103 [Direct mapping] Secreted phosphoprotein 24 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0004866 [endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:0046849 [bone remodeling] GO:0070062 [extracellular exosome] Show all	211 aa 24.3 kDa	Yes	0
SPP2-002 ENSP00000362466 ENST00000373368	Q13103 [Direct mapping] Secreted phosphoprotein 24 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0004866 [endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:0046849 [bone remodeling] GO:0070062 [extracellular exosome] Show all	211 aa 24.3 kDa	Yes	0
SPP2-004 ENSP00000417036 ENST00000425558	C9J6K0 [Direct mapping] Secreted phosphoprotein 24 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0046849 [bone remodeling] Show all	131 aa 15.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.