Expression of LIMS2 in cancer - Summary - The Human Protein Atlas

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LIMS2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LIMS2
Gene description	LIM and senescent cell antigen-like domains 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (MOLT-4, TIME)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA058340
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA058340

GENE INFORMATION
Gene name	LIMS2
Synonyms
Description	LIM and senescent cell antigen-like domains 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Chromosome	2
Cytoband	q14.3
Chromosome location (bp)	127638381 - 127681786
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072163 (version 83.38)
Entrez gene	55679
UniProt	Q7Z4I7 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z4I7
Antibodypedia	LIMS2 antibodies

PROTEIN BROWSER

LIMS2-001	LIMS2-002	LIMS2-003	LIMS2-004	LIMS2-005	LIMS2-006	LIMS2-007	LIMS2-008	LIMS2-009	LIMS2-012	LIMS2-018	LIMS2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LIMS2-001 ENSP00000347240 ENST00000355119	Q7Z4I7 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0034329 [cell junction assembly] Show all	341 aa 38.9 kDa	No	0
LIMS2-002 ENSP00000386637 ENST00000409808	Q7Z4I7 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 2 A0A024RAH1 [Target identity:100%; Query identity:100%] LIM and senescent cell antigen-like domains 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0034329 [cell junction assembly] Show all	336 aa 38.4 kDa	No	0
LIMS2-003 ENSP00000387002 ENST00000410011	Q7Z4I7 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 2 A0A024RAH1 [Target identity:100%; Query identity:100%] LIM and senescent cell antigen-like domains 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0034329 [cell junction assembly] Show all	336 aa 38.4 kDa	No	0
LIMS2-004 ENSP00000386383 ENST00000409455	Q7Z4I7 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 2 A0A024RAH1 [Target identity:100%; Query identity:100%] LIM and senescent cell antigen-like domains 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0034329 [cell junction assembly] Show all	336 aa 38.4 kDa	No	0
LIMS2-005 ENSP00000326888 ENST00000324938	Q7Z4I7 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0016337 [single organismal cell-cell adhesion] GO:0034329 [cell junction assembly] GO:0043066 [negative regulation of apoptotic process] GO:0045216 [cell-cell junction organization] GO:0050680 [negative regulation of epithelial cell proliferation] GO:2000178 [negative regulation of neural precursor cell proliferation] GO:2000346 [negative regulation of hepatocyte proliferation] GO:2001046 [positive regulation of integrin-mediated signaling pathway] Show all	365 aa 41.5 kDa	No	0
LIMS2-006 ENSP00000386570 ENST00000410038	Q7Z4I7 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0034329 [cell junction assembly] Show all	189 aa 21.6 kDa	No	0
LIMS2-007 ENSP00000397253 ENST00000426981	H0Y592 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	169 aa 18.9 kDa	No	0
LIMS2-008 ENSP00000386345 ENST00000409754	Q7Z4I7 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0034329 [cell junction assembly] Show all	189 aa 21.6 kDa	No	0
LIMS2-009 ENSP00000386252 ENST00000409286	Q7Z4I7 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0034329 [cell junction assembly] Show all	189 aa 21.6 kDa	No	0
LIMS2-012 ENSP00000386907 ENST00000409254	Q7Z4I7 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0034329 [cell junction assembly] Show all	189 aa 21.6 kDa	No	0
LIMS2-018 ENSP00000443794 ENST00000545738	Q7Z4I7 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0034329 [cell junction assembly] Show all	363 aa 41.2 kDa	No	0
LIMS2-201 ENSP00000484949 ENST00000612860	A0A087X2F9 [Direct mapping] LIM and senescent cell antigen-like-containing domain protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	249 aa 28.4 kDa	No	0

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