Tissue expression of ALDH3A2 - Summary - The Human Protein Atlas

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ALDH3A2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ALDH3A2
Gene description	Aldehyde dehydrogenase 3 family, member A2
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA014769 , CAB020692
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ALDH3A2 (HGNC Symbol)
Synonyms	ALDH10, ALDH3A2, FALDH , SLS
Description	Aldehyde dehydrogenase 3 family, member A2 (HGNC Symbol)
Entrez gene summary	Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	19648136 - 19677598
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072210 (version 83.38)
Entrez gene	224
UniProt	P51648 (UniProt - Evidence at protein level)
neXtProt	NX_P51648
Antibodypedia	ALDH3A2 antibodies

PROTEIN BROWSER

ALDH3A2-001	ALDH3A2-002	ALDH3A2-004	ALDH3A2-006	ALDH3A2-008	ALDH3A2-010	ALDH3A2-012	ALDH3A2-017	ALDH3A2-018	ALDH3A2-020	ALDH3A2-022	ALDH3A2-024	ALDH3A2-201	ALDH3A2-202	ALDH3A2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALDH3A2-001 ENSP00000176643 ENST00000176643	P51648 [Direct mapping] Fatty aldehyde dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity] GO:0005777 [peroxisome] GO:0005789 [endoplasmic reticulum membrane] GO:0006081 [cellular aldehyde metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0006714 [sesquiterpenoid metabolic process] GO:0007417 [central nervous system development] GO:0007422 [peripheral nervous system development] GO:0008152 [metabolic process] GO:0008544 [epidermis development] GO:0016491 [oxidoreductase activity] GO:0030148 [sphingolipid biosynthetic process] GO:0033306 [phytol metabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0046577 [long-chain-alcohol oxidase activity] GO:0050061 [long-chain-aldehyde dehydrogenase activity] GO:0052814 [medium-chain-aldehyde dehydrogenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	485 aa 54.8 kDa	No	3
ALDH3A2-002 ENSP00000345774 ENST00000339618	P51648 [Direct mapping] Fatty aldehyde dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000302 [response to reactive oxygen species] GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005777 [peroxisome] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006081 [cellular aldehyde metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0006714 [sesquiterpenoid metabolic process] GO:0007417 [central nervous system development] GO:0007422 [peripheral nervous system development] GO:0008152 [metabolic process] GO:0008544 [epidermis development] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0030148 [sphingolipid biosynthetic process] GO:0033306 [phytol metabolic process] GO:0042406 [extrinsic component of endoplasmic reticulum membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0046292 [formaldehyde metabolic process] GO:0046577 [long-chain-alcohol oxidase activity] GO:0050061 [long-chain-aldehyde dehydrogenase activity] GO:0052814 [medium-chain-aldehyde dehydrogenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	508 aa 57.7 kDa	No	3
ALDH3A2-004 ENSP00000378942 ENST00000395575	P51648 [Direct mapping] Fatty aldehyde dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity] GO:0005777 [peroxisome] GO:0005789 [endoplasmic reticulum membrane] GO:0006081 [cellular aldehyde metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0006714 [sesquiterpenoid metabolic process] GO:0007417 [central nervous system development] GO:0007422 [peripheral nervous system development] GO:0008152 [metabolic process] GO:0008544 [epidermis development] GO:0016491 [oxidoreductase activity] GO:0030148 [sphingolipid biosynthetic process] GO:0033306 [phytol metabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0046577 [long-chain-alcohol oxidase activity] GO:0050061 [long-chain-aldehyde dehydrogenase activity] GO:0052814 [medium-chain-aldehyde dehydrogenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	485 aa 54.8 kDa	No	3
ALDH3A2-006 ENSP00000395845 ENST00000446398	C9JGJ2 [Direct mapping] Fatty aldehyde dehydrogenase Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	166 aa 18.7 kDa	No	0
ALDH3A2-008 ENSP00000458942 ENST00000571537	I3L1M4 [Direct mapping] Fatty aldehyde dehydrogenase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	162 aa 18.5 kDa	No	0
ALDH3A2-010 ENSP00000459977 ENST00000571163	I3L2W1 [Direct mapping] Fatty aldehyde dehydrogenase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	97 aa 10.8 kDa	No	0
ALDH3A2-012 ENSP00000461235 ENST00000575384	I3L4G6 [Direct mapping] Fatty aldehyde dehydrogenase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0016021 [integral component of membrane] GO:0055114 [oxidation-reduction process] Show all	85 aa 9.6 kDa	No	1
ALDH3A2-017 ENSP00000462964 ENST00000580550	J3KTG1 [Direct mapping] Fatty aldehyde dehydrogenase Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	146 aa 16.5 kDa	No	0
ALDH3A2-018 ENSP00000466814 ENST00000584332	K7EN73 [Direct mapping] Fatty aldehyde dehydrogenase Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	127 aa 14.1 kDa	No	0
ALDH3A2-020 ENSP00000464453 ENST00000578696	J3QS00 [Direct mapping] Fatty aldehyde dehydrogenase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	134 aa 15.1 kDa	No	0
ALDH3A2-022 ENSP00000463637 ENST00000579855	P51648 [Direct mapping] Fatty aldehyde dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity] GO:0005777 [peroxisome] GO:0005789 [endoplasmic reticulum membrane] GO:0006081 [cellular aldehyde metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0006714 [sesquiterpenoid metabolic process] GO:0007417 [central nervous system development] GO:0007422 [peripheral nervous system development] GO:0008152 [metabolic process] GO:0008544 [epidermis development] GO:0016491 [oxidoreductase activity] GO:0030148 [sphingolipid biosynthetic process] GO:0033306 [phytol metabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0046577 [long-chain-alcohol oxidase activity] GO:0050061 [long-chain-aldehyde dehydrogenase activity] GO:0052814 [medium-chain-aldehyde dehydrogenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	485 aa 54.8 kDa	No	3
ALDH3A2-024 ENSP00000461916 ENST00000581518	P51648 [Direct mapping] Fatty aldehyde dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity] GO:0005777 [peroxisome] GO:0005789 [endoplasmic reticulum membrane] GO:0006081 [cellular aldehyde metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0006714 [sesquiterpenoid metabolic process] GO:0007417 [central nervous system development] GO:0007422 [peripheral nervous system development] GO:0008152 [metabolic process] GO:0008544 [epidermis development] GO:0016491 [oxidoreductase activity] GO:0030148 [sphingolipid biosynthetic process] GO:0033306 [phytol metabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0046577 [long-chain-alcohol oxidase activity] GO:0050061 [long-chain-aldehyde dehydrogenase activity] GO:0052814 [medium-chain-aldehyde dehydrogenase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	508 aa 57.7 kDa	No	4
ALDH3A2-201 ENSP00000486283 ENST00000626500	I3L0X1 [Direct mapping] Fatty aldehyde dehydrogenase Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	182 aa 20.7 kDa	No	0
ALDH3A2-202 ENSP00000487353 ENST00000630662	I3L2W1 [Direct mapping] Fatty aldehyde dehydrogenase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	97 aa 10.8 kDa	No	0
ALDH3A2-203 ENSP00000486085 ENST00000631291	J3QRD1 [Direct mapping] Fatty aldehyde dehydrogenase Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	393 aa 44.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.