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TRPC5

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GENERAL INFORMATION

Gene name

 TRPC5

Gene description

 Transient receptor potential cation channel, subfamily C, member 5

Protein class

 Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 TRPC5 (HGNC Symbol)

Synonyms

 PPP1R159

Description

 Transient receptor potential cation channel, subfamily C, member 5 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]

Chromosome

 X

Cytoband

 q23

Chromosome location (bp)

 111774315 - 112082776

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072315 (version 83.38)

Entrez gene

 7224

UniProt

 Q9UL62 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UL62

Antibodypedia

 TRPC5 antibodies

PROTEIN BROWSER
TRPC5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRPC5-001
ENSP00000262839
ENST00000262839
Q9UL62 [Direct mapping]
Short transient receptor potential channel 5
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0034704 [calcium channel complex]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 973 aa
111.4 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.