Cell atlas - MPP5 - The Human Protein Atlas

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MPP5

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	MPP5
Gene description	Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (uncertain)
Additional location	In addition localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA000993
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.

Main location

Nucleoplasm (uncertain)

Additional location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA000993	A-431	Nucleoplasm
			Plasma membrane
			Cytosol
	HPA000993	U-2 OS	Nucleoplasm
			Plasma membrane
			Cytosol
	HPA000993	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	MPP5 (HGNC Symbol)
Synonyms	FLJ12615, PALS1
Description	Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Chromosome	14
Cytoband	q23.3
Chromosome location (bp)	67241109 - 67335819
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072415 (version 83.38)
Entrez gene	64398
UniProt	Q8N3R9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N3R9
Antibodypedia	MPP5 antibodies

PROTEIN BROWSER

MPP5-001	MPP5-002	MPP5-004	MPP5-006	MPP5-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPP5-001 ENSP00000261681 ENST00000261681	Q8N3R9 [Direct mapping] MAGUK p55 subfamily member 5 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002011 [morphogenesis of an epithelial sheet] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0007009 [plasma membrane organization] GO:0012505 [endomembrane system] GO:0019904 [protein domain specific binding] GO:0032287 [peripheral nervous system myelin maintenance] GO:0032288 [myelin assembly] GO:0034329 [cell junction assembly] GO:0035749 [myelin sheath adaxonal region] GO:0035750 [protein localization to myelin sheath abaxonal region] GO:0043219 [lateral loop] GO:0043220 [Schmidt-Lanterman incisure] GO:0043234 [protein complex] GO:0045216 [cell-cell junction organization] GO:0070062 [extracellular exosome] GO:0070830 [bicellular tight junction assembly] GO:0090002 [establishment of protein localization to plasma membrane] Show all	675 aa 77.3 kDa	No	0
MPP5-002 ENSP00000450550 ENST00000556345	G3V2B0 [Direct mapping] MAGUK p55 subfamily member 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		124 aa 14.3 kDa	No	0
MPP5-004 ENSP00000451488 ENST00000555925	Q8N3R9 [Direct mapping] MAGUK p55 subfamily member 5 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002011 [morphogenesis of an epithelial sheet] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0012505 [endomembrane system] GO:0019904 [protein domain specific binding] GO:0034329 [cell junction assembly] GO:0045216 [cell-cell junction organization] GO:0070062 [extracellular exosome] GO:0070830 [bicellular tight junction assembly] Show all	641 aa 73.4 kDa	No	0
MPP5-006 ENSP00000451571 ENST00000557237		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		4 aa 0.4 kDa	No	0
MPP5-007 ENSP00000450656 ENST00000557783	G3V2H1 [Direct mapping] MAGUK p55 subfamily member 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	149 aa 17.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.