Fields »
ABOUT
HELP
BLOG
HSD17B10

GENERAL INFORMATION

Gene name

 HSD17B10

Gene description

 Hydroxysteroid (17-beta) dehydrogenase 10

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA001432
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001432

GENE INFORMATION

Gene name

 HSD17B10 (HGNC Symbol)

Synonyms

 17b-HSD10, ABAD, CAMR, ERAB, HADH2, MHBD, MRPP2, MRXS10, SDR5C1

Description

 Hydroxysteroid (17-beta) dehydrogenase 10 (HGNC Symbol)

Entrez gene summary

 This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]

Chromosome

 X

Cytoband

 p11.22

Chromosome location (bp)

 53431258 - 53434373

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072506 (version 83.38)

Entrez gene

 3028

UniProt

 Q99714 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99714

Antibodypedia

 HSD17B10 antibodies

PROTEIN BROWSER
HSD17B10-001
HSD17B10-002
HSD17B10-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSD17B10-001
ENSP00000168216
ENST00000168216
Q99714 [Direct mapping]
3-hydroxyacyl-CoA dehydrogenase type-2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity]
GO:0004303 [estradiol 17-beta-dehydrogenase activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0007569 [cell aging]
GO:0008033 [tRNA processing]
GO:0008152 [metabolic process]
GO:0008709 [cholate 7-alpha-dehydrogenase activity]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0016491 [oxidoreductase activity]
GO:0018454 [acetoacetyl-CoA reductase activity]
GO:0030283 [testosterone dehydrogenase [NAD(P)] activity]
GO:0030331 [estrogen receptor binding]
GO:0033327 [Leydig cell differentiation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042645 [mitochondrial nucleoid]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0047015 [3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity]
GO:0051287 [NAD binding]
GO:0051289 [protein homotetramerization]
GO:0055114 [oxidation-reduction process]
Show all
 261 aa
26.9 kDa 		No 0
HSD17B10-002
ENSP00000364453
ENST00000375304
Q99714 [Direct mapping]
3-hydroxyacyl-CoA dehydrogenase type-2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0008033 [tRNA processing]
GO:0008152 [metabolic process]
GO:0008709 [cholate 7-alpha-dehydrogenase activity]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0016491 [oxidoreductase activity]
GO:0030283 [testosterone dehydrogenase [NAD(P)] activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0047015 [3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity]
GO:0055114 [oxidation-reduction process]
Show all
 252 aa
26 kDa 		No 0
HSD17B10-004
ENSP00000364447
ENST00000375298
Q5H928 [Direct mapping]
3-hydroxyacyl-CoA dehydrogenase type-2; Hydroxysteroid (17-beta) dehydrogenase 10
Show all
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 169 aa
17.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.