Tissue expression of CHFR - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CHFR
Gene description	Checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CHFR (HGNC Symbol)
Synonyms	FLJ10796, RNF196
Description	Checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary	This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]
Chromosome	12
Cytoband	q24.33
Chromosome location (bp)	132822187 - 132956304
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072609 (version 83.38)
Entrez gene	55743
UniProt	Q96EP1 (UniProt - Evidence at protein level)
neXtProt	NX_Q96EP1
Antibodypedia	CHFR antibodies

PROTEIN BROWSER

CHFR-001	CHFR-002	CHFR-003	CHFR-004	CHFR-005	CHFR-012	CHFR-013	CHFR-014	CHFR-027

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHFR-001 ENSP00000266880 ENST00000266880	Q96EP1 [Direct mapping] E3 ubiquitin-protein ligase CHFR Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000209 [protein polyubiquitination] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007067 [mitotic nuclear division] GO:0007093 [mitotic cell cycle checkpoint] GO:0008270 [zinc ion binding] GO:0016605 [PML body] GO:0016874 [ligase activity] GO:0019941 [modification-dependent protein catabolic process] GO:0051301 [cell division] Show all	623 aa 69.2 kDa	No	0
CHFR-002 ENSP00000392395 ENST00000432561	Q96EP1 [Direct mapping] E3 ubiquitin-protein ligase CHFR Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007067 [mitotic nuclear division] GO:0007093 [mitotic cell cycle checkpoint] GO:0008270 [zinc ion binding] GO:0016605 [PML body] GO:0016874 [ligase activity] GO:0019941 [modification-dependent protein catabolic process] GO:0031398 [positive regulation of protein ubiquitination] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0051301 [cell division] GO:0061630 [ubiquitin protein ligase activity] Show all	664 aa 73.4 kDa	No	0
CHFR-003 ENSP00000398735 ENST00000450056	Q96EP1 [Direct mapping] E3 ubiquitin-protein ligase CHFR Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000209 [protein polyubiquitination] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007067 [mitotic nuclear division] GO:0007093 [mitotic cell cycle checkpoint] GO:0008270 [zinc ion binding] GO:0016605 [PML body] GO:0016874 [ligase activity] GO:0019941 [modification-dependent protein catabolic process] GO:0051301 [cell division] Show all	652 aa 72 kDa	No	0
CHFR-004 ENSP00000416431 ENST00000443047	Q96EP1 [Direct mapping] E3 ubiquitin-protein ligase CHFR Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000209 [protein polyubiquitination] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007067 [mitotic nuclear division] GO:0007093 [mitotic cell cycle checkpoint] GO:0008270 [zinc ion binding] GO:0016605 [PML body] GO:0016874 [ligase activity] GO:0019941 [modification-dependent protein catabolic process] GO:0051301 [cell division] Show all	572 aa 63.9 kDa	No	0
CHFR-005 ENSP00000443237 ENST00000540537	F5H5P5 [Direct mapping] E3 ubiquitin-protein ligase CHFR Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.6 kDa	No	0
CHFR-012 ENSP00000445371 ENST00000541817	F5H375 [Direct mapping] E3 ubiquitin-protein ligase CHFR Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		137 aa 13.9 kDa	No	0
CHFR-013 ENSP00000443761 ENST00000542714	F5H829 [Direct mapping] E3 ubiquitin-protein ligase CHFR Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		72 aa 7.4 kDa	No	0
CHFR-014 ENSP00000441837 ENST00000540963	F5GWH4 [Direct mapping] E3 ubiquitin-protein ligase CHFR Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	223 aa 23.7 kDa	No	0
CHFR-027 ENSP00000475247 ENST00000536932	U3KPU9 [Direct mapping] E3 ubiquitin-protein ligase CHFR Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.1 kDa	No	0