Expression of FCGR2B in cancer - Summary

GENERAL INFORMATION
Gene name	FCGR2B
Gene description	Fc fragment of IgG, low affinity IIb, receptor (CD32)
Protein class	Cancer-related genes CD markers Disease related genes FDA approved drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (Daudi, HMC-1, RPMI-8226)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in endothelial cells in placenta and subsets of lymphoid cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA014730 , CAB007796
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA014730	CAB007796

GENE INFORMATION
Gene name	FCGR2B (HGNC Symbol)
Synonyms	CD32, CD32B, FCG2, FCGR2
Description	Fc fragment of IgG, low affinity IIb, receptor (CD32) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	161663147 - 161678654
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072694 (version 83.38)
Entrez gene	2213
UniProt	P31994 (UniProt - Evidence at protein level)
neXtProt	NX_P31994
Antibodypedia	FCGR2B antibodies

PROTEIN BROWSER

FCGR2B-001	FCGR2B-002	FCGR2B-005	FCGR2B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCGR2B-001 ENSP00000356938 ENST00000367961	P31994 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor II-b Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0019864 [IgG binding] GO:0050776 [regulation of immune response] Show all	303 aa 33.4 kDa	No	1
FCGR2B-002 ENSP00000351497 ENST00000358671	P31994 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor II-b Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0019864 [IgG binding] GO:0050776 [regulation of immune response] Show all	310 aa 34 kDa	Yes	1
FCGR2B-005 ENSP00000236937 ENST00000236937	P31994 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor II-b Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0019864 [IgG binding] GO:0050776 [regulation of immune response] Show all	291 aa 31.9 kDa	Yes	1
FCGR2B-201 ENSP00000404329 ENST00000428605	P31994 [Direct mapping] Low affinity immunoglobulin gamma Fc region receptor II-b Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0019864 [IgG binding] GO:0050776 [regulation of immune response] Show all	310 aa 34 kDa	Yes	1