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ACAP1

GENERAL INFORMATION

Gene name

 ACAP1

Gene description

 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HDLM-2, NB-4)
HPA (normal tissue):Tissue enhanced (lymph node)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable), head and neck cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Head and neck cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ACAP1 (HGNC Symbol)

Synonyms

 CENTB1, KIAA0050

Description

 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7336529 - 7351478

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072818 (version 83.38)

Entrez gene

 9744

UniProt

 Q15027 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15027

Antibodypedia

 ACAP1 antibodies

PROTEIN BROWSER
ACAP1-001
ACAP1-003
ACAP1-004
ACAP1-009
ACAP1-010
ACAP1-011
ACAP1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACAP1-001
ENSP00000158762
ENST00000158762
Q15027 [Direct mapping]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:0055038 [recycling endosome membrane]
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 740 aa
81.5 kDa 		No 0
ACAP1-003
ENSP00000458173
ENST00000570457
I3L0K9 [Direct mapping]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 148 aa
17 kDa 		No 0
ACAP1-004
ENSP00000459422
ENST00000575425
I3L268 [Direct mapping]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 101 aa
11.4 kDa 		No 0
ACAP1-009
ENSP00000461314
ENST00000571471
I3L2Z4 [Direct mapping]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 44 aa
5 kDa 		No 0
ACAP1-010
ENSP00000460803
ENST00000574499
I3L3X6 [Direct mapping]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 65 aa
7.4 kDa 		No 0
ACAP1-011
ENSP00000460054
ENST00000575415
I3L2Z4 [Direct mapping]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 44 aa
5 kDa 		No 0
ACAP1-012
ENSP00000460735
ENST00000570504
I3L2Z4 [Direct mapping]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 44 aa
5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.