Cell atlas - MRVI1 - The Human Protein Atlas

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MRVI1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MRVI1
Gene description	Murine retrovirus integration site 1 homolog
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the nuclear bodies.
RNA cell category	Cell line enhanced (BJ hTERT+, BJ, REH)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Nuclear bodies (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA008704
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ hTERT+, BJ, REH) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the nuclear bodies.

Main location

Cytosol (approved)

Additional location

Nuclear bodies (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA008704	BJ	Nuclear bodies
	HPA008704	BJ	Cytosol
	HPA008704	U-2 OS	Nuclear bodies
	HPA008704	U-2 OS	Cytosol
	HPA008704	U-251 MG	Nuclear bodies
	HPA008704	U-251 MG	Cytosol

GENE INFORMATION
Gene name	MRVI1 (HGNC Symbol)
Synonyms	IRAG, JAW1L
Description	Murine retrovirus integration site 1 homolog (HGNC Symbol)
Entrez gene summary	This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	10573091 - 10693988
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000072952 (version 83.38)
Entrez gene	10335
UniProt	Q9Y6F6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6F6
Antibodypedia	MRVI1 antibodies

PROTEIN BROWSER

MRVI1-001	MRVI1-002	MRVI1-005	MRVI1-008	MRVI1-013	MRVI1-014	MRVI1-015	MRVI1-201	MRVI1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRVI1-001 ENSP00000412130 ENST00000423302	Q9Y6F6 [Direct mapping] Protein MRVI1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005789 [endoplasmic reticulum membrane] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0019934 [cGMP-mediated signaling] GO:0031095 [platelet dense tubular network membrane] GO:0045986 [negative regulation of smooth muscle contraction] GO:0048471 [perinuclear region of cytoplasm] GO:0060087 [relaxation of vascular smooth muscle] Show all	912 aa 98.9 kDa	No	1
MRVI1-002 ENSP00000432436 ENST00000531107	Q9Y6F6 [Direct mapping] Protein MRVI1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	904 aa 98 kDa	No	1
MRVI1-005 ENSP00000433296 ENST00000534266	Q9Y6F6 [Direct mapping] Protein MRVI1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	597 aa 65.9 kDa	No	1
MRVI1-008 ENSP00000432325 ENST00000529547	E9PRG4 [Direct mapping] Protein MRVI1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 7.2 kDa	No	0
MRVI1-013 ENSP00000437784 ENST00000541483	Q9Y6F6 [Direct mapping] Protein MRVI1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	706 aa 76.9 kDa	No	1
MRVI1-014 ENSP00000432067 ENST00000527509	H0YI08 [Direct mapping] Protein MRVI1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	821 aa 89.7 kDa	No	1
MRVI1-015 ENSP00000453013 ENST00000558540	Q9Y6F6 [Direct mapping] Protein MRVI1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	597 aa 65.9 kDa	No	1
MRVI1-201 ENSP00000401205 ENST00000424001	Q9Y6F6 [Direct mapping] Protein MRVI1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	597 aa 65.9 kDa	No	1
MRVI1-202 ENSP00000448278 ENST00000547195	Q9Y6F6 [Direct mapping] Protein MRVI1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	597 aa 65.9 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.