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AP1M1

GENERAL INFORMATION

Gene name

 AP1M1

Gene description

 Adaptor-related protein complex 1, mu 1 subunit

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA045256
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045256

GENE INFORMATION

Gene name

 AP1M1 (HGNC Symbol)

Synonyms

 AP47, CLAPM2

Description

 Adaptor-related protein complex 1, mu 1 subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 16197578 - 16245907

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000072958 (version 83.38)

Entrez gene

 8907

UniProt

 Q9BXS5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BXS5

Antibodypedia

 AP1M1 antibodies

PROTEIN BROWSER
AP1M1-001
AP1M1-002
AP1M1-003
AP1M1-004
AP1M1-005
AP1M1-007
AP1M1-008
AP1M1-009
AP1M1-011
AP1M1-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP1M1-001
ENSP00000291439
ENST00000291439
Q9BXS5 [Direct mapping]
AP-1 complex subunit mu-1
A0A024R7K8 [Target identity:100%; Query identity:100%]
Adaptor-related protein complex 1, mu 1 subunit, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032438 [melanosome organization]
GO:0032588 [trans-Golgi network membrane]
GO:0035646 [endosome to melanosome transport]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
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 423 aa
48.6 kDa 		No 0
AP1M1-002
ENSP00000411498
ENST00000429941
E7ENJ6 [Direct mapping]
AP-1 complex subunit mu-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
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 370 aa
42.6 kDa 		No 0
AP1M1-003
ENSP00000465224
ENST00000590756
K7EJL1 [Direct mapping]
AP-1 complex subunit mu-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
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 351 aa
40.3 kDa 		No 0
AP1M1-004
ENSP00000388996
ENST00000444449
Q9BXS5 [Direct mapping]
AP-1 complex subunit mu-1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030131 [clathrin adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032438 [melanosome organization]
GO:0032588 [trans-Golgi network membrane]
GO:0035646 [endosome to melanosome transport]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
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 435 aa
49.8 kDa 		No 0
AP1M1-005
ENSP00000466858
ENST00000590263
K7ENA7 [Direct mapping]
AP-1 complex subunit mu-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
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 136 aa
15.8 kDa 		No 0
AP1M1-007
ENSP00000468140
ENST00000589822
K7ER75 [Direct mapping]
AP-1 complex subunit mu-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006810 [transport]
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 105 aa
12.3 kDa 		No 0
AP1M1-008
ENSP00000467721
ENST00000590945
K7EQ90 [Direct mapping]
AP-1 complex subunit mu-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006810 [transport]
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 64 aa
7.4 kDa 		No 0
AP1M1-009
ENSP00000467417
ENST00000591775
K7EPJ8 [Direct mapping]
AP-1 complex subunit mu-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006810 [transport]
GO:0015031 [protein transport]
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 125 aa
14.5 kDa 		No 0
AP1M1-011
ENSP00000482949
ENST00000589782
A0A087WZX7 [Direct mapping]
AP-1 complex subunit mu-1
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   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
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 128 aa
14.8 kDa 		No 0
AP1M1-014
ENSP00000468015
ENST00000586543
K7EQX3 [Direct mapping]
AP-1 complex subunit mu-1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
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 176 aa
20 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.