Fields »
ABOUT
HELP
BLOG
PVR

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 PVR

Gene description

 Poliovirus receptor

Protein class

 CD markers
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane, nucleoplasm & vesicles.

RNA cell category

 Cell line enhanced (TIME)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved), Vesicles (approved), Plasma membrane (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA012568
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane, nucleoplasm & vesicles.

Main location

 Nucleoplasm (approved), Vesicles (approved), Plasma membrane (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA012568 A-431 Nucleoplasm
Vesicles
Plasma membrane
HPA012568 U-2 OS Nucleoplasm
HPA012568 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 PVR (HGNC Symbol)

Synonyms

 CD155, HVED, Necl-5, NECL5, PVS, Tage4

Description

 Poliovirus receptor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Chromosome

 19

Cytoband

 q13.31

Chromosome location (bp)

 44643798 - 44663583

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000073008 (version 83.38)

Entrez gene

 5817

UniProt

 P15151 (UniProt - Evidence at protein level)

neXtProt

 NX_P15151

Antibodypedia

 PVR antibodies

PROTEIN BROWSER
PVR-001
PVR-003
PVR-004
PVR-005
PVR-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PVR-001
ENSP00000402060
ENST00000425690
A0A0C4DG49 [Direct mapping]
Poliovirus receptor; Poliovirus receptor, isoform CRA_c
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
 417 aa
45.3 kDa 		Yes 1
PVR-003
ENSP00000383907
ENST00000406449
A0A0A0MSA9 [Direct mapping]
Poliovirus receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
 392 aa
42.9 kDa 		Yes 1
PVR-004
ENSP00000385344
ENST00000403059
P15151 [Direct mapping]
Poliovirus receptor
Show all
CD markers
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002860 [positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target]
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0005925 [focal adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0008037 [cell recognition]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042271 [susceptibility to natural killer cell mediated cytotoxicity]
GO:0042803 [protein homodimerization activity]
GO:0045216 [cell-cell junction organization]
GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity]
GO:0046718 [viral entry into host cell]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0060370 [susceptibility to T cell mediated cytotoxicity]
GO:0070062 [extracellular exosome]
Show all
 372 aa
40.1 kDa 		Yes 0
PVR-005
ENSP00000466447
ENST00000587785
K7EMC6 [Direct mapping]
Poliovirus receptor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 70 aa
7.9 kDa 		No 0
PVR-006
ENSP00000340870
ENST00000344956
P15151 [Direct mapping]
Poliovirus receptor
Show all
CD markers
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0002860 [positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target]
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0005925 [focal adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0008037 [cell recognition]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042271 [susceptibility to natural killer cell mediated cytotoxicity]
GO:0042803 [protein homodimerization activity]
GO:0045216 [cell-cell junction organization]
GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity]
GO:0046718 [viral entry into host cell]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0060370 [susceptibility to T cell mediated cytotoxicity]
GO:0070062 [extracellular exosome]
Show all
 364 aa
39.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.