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TP63

GENERAL INFORMATION

Gene name

 TP63

Gene description

 Tumor protein p63

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 12
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (esophagus, skin)
GTEx:Tissue enhanced (esophagus, skin, vagina)
FANTOM5:Tissue enhanced (esophagus, skeletal muscle, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several tissues including squamous and respiratory epithelia and myoepithelial cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA006288 , HPA007010 , CAB000083
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skeletal muscle, tonsil)

GENE INFORMATION

Gene name

 TP63 (HGNC Symbol)

Synonyms

 EEC3, KET, NBP, OFC8, p51, p53CP, p63, p73H, p73L, SHFM4, TP53CP, TP53L, TP73L

Description

 Tumor protein p63 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q28

Chromosome location (bp)

 189631416 - 189897279

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000073282 (version 83.38)

Entrez gene

 8626

UniProt

 Q9H3D4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H3D4

Antibodypedia

 TP63 antibodies

PROTEIN BROWSER
«
TP63-001
TP63-002
TP63-003
TP63-004
TP63-007
TP63-008
TP63-009
TP63-010
TP63-011
TP63-012
TP63-013
TP63-015
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TP63-001
ENSP00000264731
ENST00000264731
Q9H3D4 [Direct mapping]
Tumor protein 63
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000989 [transcription factor activity, transcription factor binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001302 [replicative cell aging]
GO:0001501 [skeletal system development]
GO:0001736 [establishment of planar polarity]
GO:0001738 [morphogenesis of a polarized epithelium]
GO:0001942 [hair follicle development]
GO:0002039 [p53 binding]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0002064 [epithelial cell development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005791 [rough endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007219 [Notch signaling pathway]
GO:0007283 [spermatogenesis]
GO:0007389 [pattern specification process]
GO:0007499 [ectoderm and mesoderm interaction]
GO:0007569 [cell aging]
GO:0008544 [epidermis development]
GO:0009887 [organ morphogenesis]
GO:0009954 [proximal/distal pattern formation]
GO:0010165 [response to X-ray]
GO:0010259 [multicellular organismal aging]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010481 [epidermal cell division]
GO:0010482 [regulation of epidermal cell division]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0019904 [protein domain specific binding]
GO:0030154 [cell differentiation]
GO:0030216 [keratinocyte differentiation]
GO:0030326 [embryonic limb morphogenesis]
GO:0030425 [dendrite]
GO:0030850 [prostate gland development]
GO:0030855 [epithelial cell differentiation]
GO:0030859 [polarized epithelial cell differentiation]
GO:0031069 [hair follicle morphogenesis]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0036342 [post-anal tail morphogenesis]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043589 [skin morphogenesis]
GO:0043616 [keratinocyte proliferation]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045617 [negative regulation of keratinocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048485 [sympathetic nervous system development]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0048745 [smooth muscle tissue development]
GO:0048807 [female genitalia morphogenesis]
GO:0050699 [WW domain binding]
GO:0051262 [protein tetramerization]
GO:0051289 [protein homotetramerization]
GO:0051402 [neuron apoptotic process]
GO:0060157 [urinary bladder development]
GO:0060197 [cloacal septation]
GO:0060513 [prostatic bud formation]
GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development]
GO:0061436 [establishment of skin barrier]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
GO:2000271 [positive regulation of fibroblast apoptotic process]
GO:2000381 [negative regulation of mesoderm development]
GO:2000773 [negative regulation of cellular senescence]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 680 aa
76.8 kDa 		No 0
TP63-002
ENSP00000407144
ENST00000418709
Q9H3D4 [Direct mapping]
Tumor protein 63
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007219 [Notch signaling pathway]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010482 [regulation of epidermal cell division]
GO:0030425 [dendrite]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0050699 [WW domain binding]
GO:0051262 [protein tetramerization]
GO:0051289 [protein homotetramerization]
GO:0061436 [establishment of skin barrier]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
GO:2000271 [positive regulation of fibroblast apoptotic process]
GO:2000773 [negative regulation of cellular senescence]
Show all
 487 aa
55.7 kDa 		No 0
TP63-003
ENSP00000317510
ENST00000320472
Q9H3D4 [Direct mapping]
Tumor protein 63
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007219 [Notch signaling pathway]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010482 [regulation of epidermal cell division]
GO:0030425 [dendrite]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0050699 [WW domain binding]
GO:0051262 [protein tetramerization]
GO:0051289 [protein homotetramerization]
GO:0061436 [establishment of skin barrier]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
GO:2000271 [positive regulation of fibroblast apoptotic process]
GO:2000773 [negative regulation of cellular senescence]
Show all
 510 aa
57.6 kDa 		No 0
TP63-004
ENSP00000346614
ENST00000354600
Q9H3D4 [Direct mapping]
Tumor protein 63
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007219 [Notch signaling pathway]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010482 [regulation of epidermal cell division]
GO:0030425 [dendrite]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0050699 [WW domain binding]
GO:0051262 [protein tetramerization]
GO:0051289 [protein homotetramerization]
GO:0061436 [establishment of skin barrier]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
GO:2000271 [positive regulation of fibroblast apoptotic process]
GO:2000773 [negative regulation of cellular senescence]
Show all
 586 aa
65.8 kDa 		No 0
TP63-007
ENSP00000401661
ENST00000434928
C9JW72 [Direct mapping]
Tumor protein 63
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0002039 [p53 binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0030425 [dendrite]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
Show all
 183 aa
19.6 kDa 		No 0
TP63-008
ENSP00000394337
ENST00000440651
Q9H3D4 [Direct mapping]
Tumor protein 63
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007219 [Notch signaling pathway]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010482 [regulation of epidermal cell division]
GO:0030425 [dendrite]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0050699 [WW domain binding]
GO:0051262 [protein tetramerization]
GO:0051289 [protein homotetramerization]
GO:0061436 [establishment of skin barrier]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
GO:2000271 [positive regulation of fibroblast apoptotic process]
GO:2000773 [negative regulation of cellular senescence]
Show all
 676 aa
76.3 kDa 		No 0
TP63-009
ENSP00000392488
ENST00000437221
Q9H3D4 [Direct mapping]
Tumor protein 63
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007219 [Notch signaling pathway]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010482 [regulation of epidermal cell division]
GO:0030425 [dendrite]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0050699 [WW domain binding]
GO:0051262 [protein tetramerization]
GO:0051289 [protein homotetramerization]
GO:0061436 [establishment of skin barrier]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
GO:2000271 [positive regulation of fibroblast apoptotic process]
GO:2000773 [negative regulation of cellular senescence]
Show all
 393 aa
44.7 kDa 		No 0
TP63-010
ENSP00000376253
ENST00000392460
Q9H3D4 [Direct mapping]
Tumor protein 63
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007219 [Notch signaling pathway]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010482 [regulation of epidermal cell division]
GO:0030425 [dendrite]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0050699 [WW domain binding]
GO:0051262 [protein tetramerization]
GO:0051289 [protein homotetramerization]
GO:0061436 [establishment of skin barrier]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
GO:2000271 [positive regulation of fibroblast apoptotic process]
GO:2000773 [negative regulation of cellular senescence]
Show all
 555 aa
62.4 kDa 		No 0
TP63-011
ENSP00000376256
ENST00000392463
Q9H3D4 [Direct mapping]
Tumor protein 63
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007219 [Notch signaling pathway]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010482 [regulation of epidermal cell division]
GO:0030425 [dendrite]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0050699 [WW domain binding]
GO:0051262 [protein tetramerization]
GO:0051289 [protein homotetramerization]
GO:0061436 [establishment of skin barrier]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
GO:2000271 [positive regulation of fibroblast apoptotic process]
GO:2000773 [negative regulation of cellular senescence]
Show all
 461 aa
51.4 kDa 		No 0
TP63-012
ENSP00000387839
ENST00000449992
Q9H3D4 [Direct mapping]
Tumor protein 63
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007219 [Notch signaling pathway]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010482 [regulation of epidermal cell division]
GO:0030425 [dendrite]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0050699 [WW domain binding]
GO:0051262 [protein tetramerization]
GO:0051289 [protein homotetramerization]
GO:0061436 [establishment of skin barrier]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
GO:2000271 [positive regulation of fibroblast apoptotic process]
GO:2000773 [negative regulation of cellular senescence]
Show all
 501 aa
56.7 kDa 		No 0
TP63-013
ENSP00000389485
ENST00000456148
Q9H3D4 [Direct mapping]
Tumor protein 63
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007219 [Notch signaling pathway]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010482 [regulation of epidermal cell division]
GO:0030425 [dendrite]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0050699 [WW domain binding]
GO:0051262 [protein tetramerization]
GO:0051289 [protein homotetramerization]
GO:0061436 [establishment of skin barrier]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
GO:2000271 [positive regulation of fibroblast apoptotic process]
GO:2000773 [negative regulation of cellular senescence]
Show all
 582 aa
65.3 kDa 		No 0
TP63-015
ENSP00000376254
ENST00000392461
Q9H3D4 [Direct mapping]
Tumor protein 63
C9D7D0 [Target identity:100%; Query identity:100%]
Cellular tumor antigen p53
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007219 [Notch signaling pathway]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010482 [regulation of epidermal cell division]
GO:0030425 [dendrite]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0034644 [cellular response to UV]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0050699 [WW domain binding]
GO:0051262 [protein tetramerization]
GO:0051289 [protein homotetramerization]
GO:0061436 [establishment of skin barrier]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
GO:2000271 [positive regulation of fibroblast apoptotic process]
GO:2000773 [negative regulation of cellular senescence]
Show all
 416 aa
46.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.