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The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
O60658 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
O60658 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O60658 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O60658 [Direct mapping] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
