Expression of CLCN4 in cancer - Summary - The Human Protein Atlas

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CLCN4

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLCN4
Gene description	Chloride channel, voltage-sensitive 4
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HEL, SCLC-21H)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, epididymis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in neuronal cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.
Reliability score	Supported based on 1 antibody. HPA031313
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and pancreatic cancer (favourable).
Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031313

GENE INFORMATION
Gene name	CLCN4 (HGNC Symbol)
Synonyms	ClC-4, CLC4
Description	Chloride channel, voltage-sensitive 4 (HGNC Symbol)
Entrez gene summary	The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]
Chromosome	X
Cytoband	p22.2
Chromosome location (bp)	10156945 - 10237660
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000073464 (version 83.38)
Entrez gene	1183
UniProt	P51793 (UniProt - Evidence at protein level)
neXtProt	NX_P51793
Antibodypedia	CLCN4 antibodies

PROTEIN BROWSER

CLCN4-001	CLCN4-002	CLCN4-003	CLCN4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLCN4-001 ENSP00000370213 ENST00000380833	P51793 [Direct mapping] H(+)/Cl(-) exchange transporter 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005254 [chloride channel activity] GO:0005524 [ATP binding] GO:0006810 [transport] GO:0006821 [chloride transport] GO:0010008 [endosome membrane] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031901 [early endosome membrane] GO:0031902 [late endosome membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	760 aa 84.9 kDa	No	>9
CLCN4-002 ENSP00000403064 ENST00000454850	E9PFB5 [Direct mapping] H(+)/Cl(-) exchange transporter 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	152 aa 17.2 kDa	No	1
CLCN4-003 ENSP00000370209 ENST00000380829	G3XAG5 [Direct mapping] Chloride channel protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	729 aa 81.3 kDa	No	>9
CLCN4-201 ENSP00000405754 ENST00000421085	P51793 [Direct mapping] H(+)/Cl(-) exchange transporter 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005254 [chloride channel activity] GO:0005524 [ATP binding] GO:0006810 [transport] GO:0006821 [chloride transport] GO:0010008 [endosome membrane] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031901 [early endosome membrane] GO:0031902 [late endosome membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	666 aa 74.3 kDa	No	>9

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The Human Protein Atlas

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