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NLE1

GENERAL INFORMATION

Gene name

 NLE1

Gene description

 Notchless homolog 1 (Drosophila)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA018807
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and urothelial cancer (unfavourable).
Liver cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018807

GENE INFORMATION

Gene name

 NLE1 (HGNC Symbol)

Synonyms

 FLJ10458

Description

 Notchless homolog 1 (Drosophila) (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 q12

Chromosome location (bp)

 35128753 - 35142315

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000073536 (version 83.38)

Entrez gene

 54475

UniProt

 Q9NVX2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NVX2

Antibodypedia

 NLE1 antibodies

PROTEIN BROWSER
NLE1-001
NLE1-003
NLE1-004
NLE1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NLE1-001
ENSP00000413572
ENST00000442241
Q9NVX2 [Direct mapping]
Notchless protein homolog 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001756 [somitogenesis]
GO:0001822 [kidney development]
GO:0001826 [inner cell mass cell differentiation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0007219 [Notch signaling pathway]
GO:0042273 [ribosomal large subunit biogenesis]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0048705 [skeletal system morphogenesis]
GO:0061484 [hematopoietic stem cell homeostasis]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
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 485 aa
53.3 kDa 		No 0
NLE1-003
ENSP00000466764
ENST00000588019
K7EN33 [Direct mapping]
Notchless protein homolog 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 304 aa
33.4 kDa 		No 0
NLE1-004
ENSP00000466588
ENST00000586869
Q9NVX2 [Direct mapping]
Notchless protein homolog 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
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 193 aa
21.3 kDa 		No 0
NLE1-005
ENSP00000354075
ENST00000360831
A0A0A0MRH0 [Direct mapping]
Notchless protein homolog 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
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 443 aa
48.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.