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SDHA

GENERAL INFORMATION

Gene name

 SDHA

Gene description

 Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

Protein class

 Citric acid cycle related proteins
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041981 , CAB034929
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (unfavourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA041981
CAB034929

GENE INFORMATION

Gene name

 SDHA (HGNC Symbol)

Synonyms

 FP, SDH2, SDHF

Description

 Succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (HGNC Symbol)

Entrez gene summary

 This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Chromosome

 5

Cytoband

 p15.33

Chromosome location (bp)

 218241 - 256700

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000073578 (version 83.38)

Entrez gene

 6389

UniProt

 P31040 (UniProt - Evidence at protein level)

neXtProt

 NX_P31040

Antibodypedia

 SDHA antibodies

PROTEIN BROWSER
SDHA-001
SDHA-002
SDHA-004
SDHA-017
SDHA-018
SDHA-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SDHA-001
ENSP00000264932
ENST00000264932
P31040 [Direct mapping]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
A0A024QZ30 [Target identity:100%; Query identity:100%]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000104 [succinate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)]
GO:0006099 [tricarboxylic acid cycle]
GO:0006105 [succinate metabolic process]
GO:0007399 [nervous system development]
GO:0008177 [succinate dehydrogenase (ubiquinone) activity]
GO:0016491 [oxidoreductase activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0022900 [electron transport chain]
GO:0022904 [respiratory electron transport chain]
GO:0043209 [myelin sheath]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
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 664 aa
72.7 kDa 		No 0
SDHA-002
ENSP00000426514
ENST00000504309
D6RFM5 [Direct mapping]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006099 [tricarboxylic acid cycle]
GO:0008177 [succinate dehydrogenase (ubiquinone) activity]
GO:0016491 [oxidoreductase activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0022900 [electron transport chain]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
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 583 aa
63.6 kDa 		No 0
SDHA-004
ENSP00000427703
ENST00000510361
P31040 [Direct mapping]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000104 [succinate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)]
GO:0006099 [tricarboxylic acid cycle]
GO:0006105 [succinate metabolic process]
GO:0007399 [nervous system development]
GO:0008177 [succinate dehydrogenase (ubiquinone) activity]
GO:0016491 [oxidoreductase activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0022900 [electron transport chain]
GO:0022904 [respiratory electron transport chain]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 616 aa
67.3 kDa 		No 0
SDHA-017
ENSP00000422404
ENST00000515815
H0Y8X1 [Direct mapping]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
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   SignalP predicted secreted proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
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 126 aa
13.5 kDa 		No 0
SDHA-018
ENSP00000421911
ENST00000509564
H0Y8S2 [Direct mapping]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
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Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 101 aa
11.1 kDa 		No 0
SDHA-201
ENSP00000484230
ENST00000617470
A0A087X1I3 [Direct mapping]
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 519 aa
56.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.