Expression of SMARCE1 in cancer - Summary - The Human Protein Atlas

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SMARCE1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SMARCE1
Gene description	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA003916 , CAB037318
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003916	CAB037318

GENE INFORMATION
Gene name	SMARCE1 (HGNC Symbol)
Synonyms	BAF57
Description	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	40624962 - 40648508
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000073584 (version 83.38)
Entrez gene	6605
UniProt	Q969G3 (UniProt - Evidence at protein level)
neXtProt	NX_Q969G3
Antibodypedia	SMARCE1 antibodies

PROTEIN BROWSER

SMARCE1-001	SMARCE1-006	SMARCE1-008	SMARCE1-009	SMARCE1-010	SMARCE1-012	SMARCE1-013	SMARCE1-014	SMARCE1-015	SMARCE1-016	SMARCE1-017	SMARCE1-018	SMARCE1-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SMARCE1-001 ENSP00000323967 ENST00000348513	Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 A0A024R1S7 [Target identity:100%; Query identity:100%] SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000228 [nuclear chromosome] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0003682 [chromatin binding] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008080 [N-acetyltransferase activity] GO:0016514 [SWI/SNF complex] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0017053 [transcriptional repressor complex] GO:0022008 [neurogenesis] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0047485 [protein N-terminus binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:0090544 [BAF-type complex] Show all	411 aa 46.6 kDa	No	0
SMARCE1-006 ENSP00000463405 ENST00000474246	J3QL66 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		77 aa 8.3 kDa	No	0
SMARCE1-008 ENSP00000367039 ENST00000377808	Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000228 [nuclear chromosome] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0003682 [chromatin binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008080 [N-acetyltransferase activity] GO:0016514 [SWI/SNF complex] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0017053 [transcriptional repressor complex] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0047485 [protein N-terminus binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] Show all	328 aa 38 kDa	No	0
SMARCE1-009 ENSP00000466608 ENST00000264640	K7EMQ8 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0031083 [BLOC-1 complex] Show all	177 aa 20.5 kDa	No	0
SMARCE1-010 ENSP00000392958 ENST00000447024	H7C048 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0031083 [BLOC-1 complex] Show all	157 aa 18.3 kDa	No	0
SMARCE1-012 ENSP00000445370 ENST00000431889	B4DGM3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; cDNA FLJ55202, highly similar to SWI/SNF-related matrix-associatedactin-dependent regulator of chromatin subfamily E member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] Show all	393 aa 44.8 kDa	No	0
SMARCE1-013 ENSP00000462475 ENST00000580419	Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000228 [nuclear chromosome] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0003682 [chromatin binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008080 [N-acetyltransferase activity] GO:0016514 [SWI/SNF complex] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0017053 [transcriptional repressor complex] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0047485 [protein N-terminus binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] Show all	376 aa 42.8 kDa	No	0
SMARCE1-014 ENSP00000464511 ENST00000578044	Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000228 [nuclear chromosome] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0003682 [chromatin binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008080 [N-acetyltransferase activity] GO:0016514 [SWI/SNF complex] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0017053 [transcriptional repressor complex] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0047485 [protein N-terminus binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] Show all	341 aa 39.3 kDa	No	0
SMARCE1-015 ENSP00000411607 ENST00000400122	Q969G3 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Other all-alpha-helical DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000228 [nuclear chromosome] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0003682 [chromatin binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008080 [N-acetyltransferase activity] GO:0016514 [SWI/SNF complex] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0017053 [transcriptional repressor complex] GO:0031083 [BLOC-1 complex] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0047485 [protein N-terminus binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] Show all	293 aa 34.4 kDa	No	0
SMARCE1-016 ENSP00000464061 ENST00000580654	J3QR61 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 C0IMW8 [Target identity:100%; Query identity:100%] Smarce1 variant 10 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		153 aa 17.6 kDa	No	0
SMARCE1-017 ENSP00000462857 ENST00000577721	J3KT85 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		101 aa 12.1 kDa	No	0
SMARCE1-018 ENSP00000463216 ENST00000478349	J3QKS7 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0031083 [BLOC-1 complex] Show all	288 aa 33.4 kDa	No	0
SMARCE1-019 ENSP00000463282 ENST00000582955	J3QKX6 [Direct mapping] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		129 aa 14.6 kDa	No	0

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