Expression of GSDMB in cancer - Summary

GENERAL INFORMATION
Gene name	GSDMB
Gene description	Gasdermin B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (SK-BR-3)
HPA (normal tissue):	Tissue enhanced (duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in the gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 3 antibodies. HPA023925 , HPA052407 , CAB013681
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA023925	HPA052407	CAB013681

GENE INFORMATION
Gene name	GSDMB (HGNC Symbol)
Synonyms	GSDML, PRO2521
Description	Gasdermin B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Sep 2009]
Chromosome	17
Cytoband	q21.1
Chromosome location (bp)	39904595 - 39919854
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000073605 (version 83.38)
Entrez gene	55876
UniProt	Q8TAX9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TAX9
Antibodypedia	GSDMB antibodies

PROTEIN BROWSER

GSDMB-001	GSDMB-002	GSDMB-003	GSDMB-010	GSDMB-201	GSDMB-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GSDMB-001 ENSP00000377729 ENST00000394175	Q8TAX9 [Direct mapping] Gasdermin-B Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	394 aa 45 kDa	No	0
GSDMB-002 ENSP00000312584 ENST00000309481	Q8TAX9 [Direct mapping] Gasdermin-B Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	403 aa 45.8 kDa	No	0
GSDMB-003 ENSP00000353465 ENST00000360317	Q8TAX9 [Direct mapping] Gasdermin-B Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	416 aa 47.3 kDa	No	0
GSDMB-010 ENSP00000430157 ENST00000520542	Q8TAX9 [Direct mapping] Gasdermin-B Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	407 aa 46.5 kDa	No	0
GSDMB-201 ENSP00000377733 ENST00000394179	Q8TAX9 [Direct mapping] Gasdermin-B Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	403 aa 45.8 kDa	No	0
GSDMB-202 ENSP00000415049 ENST00000418519	Q8TAX9 [Direct mapping] Gasdermin-B Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	416 aa 47.3 kDa	No	0