Fields »
ABOUT
HELP
BLOG
ADAM11

GENERAL INFORMATION

Gene name

 ADAM11

Gene description

 ADAM metallopeptidase domain 11

Protein class

 Enzymes
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HEK93)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ADAM11 (HGNC Symbol)

Synonyms

 MDC

Description

 ADAM metallopeptidase domain 11 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq, Dec 2014]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 44759031 - 44781846

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000073670 (version 83.38)

Entrez gene

 4185

UniProt

 O75078 (UniProt - Evidence at transcript level)

neXtProt

 NX_O75078

Antibodypedia

 ADAM11 antibodies

PROTEIN BROWSER
ADAM11-001
ADAM11-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAM11-001
ENSP00000200557
ENST00000200557
O75078 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 11
Show all
Enzymes
   Peptidases
   Metallopeptidases
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0031012 [extracellular matrix]
Show all
 769 aa
83.4 kDa 		Yes 1
ADAM11-004
ENSP00000443773
ENST00000535346
B4DKD2 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 11; cDNA FLJ60626, highly similar to ADAM 11 (A disintegrin and metalloproteinase domain 11)
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0006508 [proteolysis]
GO:0007229 [integrin-mediated signaling pathway]
GO:0016021 [integral component of membrane]
Show all
 569 aa
61.6 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.