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ABCB11

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GENERAL INFORMATION

Gene name

 ABCB11

Gene description

 ATP-binding cassette, sub-family B (MDR/TAP), member 11

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane, cytosol & nucleoplasm.

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (uncertain), Plasma membrane (uncertain), Cytosol (uncertain)

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA019035
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane, cytosol & nucleoplasm.

Main location

 Nucleoplasm (uncertain), Plasma membrane (uncertain), Cytosol (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA019035 A-431 Nucleoplasm
Plasma membrane
Cytosol
HPA019035 U-2 OS Plasma membrane
HPA019035 U-251 MG Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 ABCB11 (HGNC Symbol)

Synonyms

 ABC16, BSEP, PFIC-2, PFIC2, PGY4, SPGP

Description

 ATP-binding cassette, sub-family B (MDR/TAP), member 11 (HGNC Symbol)

Entrez gene summary

 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 168922938 - 169031322

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000073734 (version 83.38)

Entrez gene

 8647

UniProt

 O95342 (UniProt - Evidence at protein level)

neXtProt

 NX_O95342

Antibodypedia

 ABCB11 antibodies

PROTEIN BROWSER
ABCB11-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCB11-001
ENSP00000263817
ENST00000263817
O95342 [Direct mapping]
Bile salt export pump
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006699 [bile acid biosynthetic process]
GO:0006810 [transport]
GO:0008206 [bile acid metabolic process]
GO:0008554 [sodium-exporting ATPase activity, phosphorylative mechanism]
GO:0015126 [canalicular bile acid transmembrane transporter activity]
GO:0015432 [bile acid-exporting ATPase activity]
GO:0015721 [bile acid and bile salt transport]
GO:0015722 [canalicular bile acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0035725 [sodium ion transmembrane transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0046581 [intercellular canaliculus]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
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 1321 aa
146.4 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.