Expression of CD5L in cancer - Summary - The Human Protein Atlas

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CD5L

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD5L
Gene description	CD5 molecule-like
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in macrophages.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Presumed off target binding in kidney observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA065686 , HPA068384
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA065686	HPA068384

GENE INFORMATION
Gene name	CD5L (HGNC Symbol)
Synonyms	API6, Spalpha
Description	CD5 molecule-like (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q23.1
Chromosome location (bp)	157830914 - 157898256
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000073754 (version 83.38)
Entrez gene	922
UniProt	O43866 (UniProt - Evidence at protein level)
neXtProt	NX_O43866
Antibodypedia	CD5L antibodies

PROTEIN BROWSER

CD5L-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD5L-001 ENSP00000357156 ENST00000368174	O43866 [Direct mapping] CD5 antigen-like Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006898 [receptor-mediated endocytosis] GO:0006915 [apoptotic process] GO:0006968 [cellular defense response] GO:0016020 [membrane] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	347 aa 38.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.