Expression of MAP3K13 in cancer - Summary - The Human Protein Atlas

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MAP3K13

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAP3K13
Gene description	Mitogen-activated protein kinase kinase kinase 13
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membrane expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 3 antibodies. HPA016497 , HPA036691 , HPA036692
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), pancreatic cancer (unfavourable) and ovarian cancer (favourable).
Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016497	HPA036691	HPA036692

GENE INFORMATION
Gene name	MAP3K13 (HGNC Symbol)
Synonyms	LZK, MEKK13
Description	Mitogen-activated protein kinase kinase kinase 13 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q27.2
Chromosome location (bp)	185282941 - 185489097
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000073803 (version 83.38)
Entrez gene	9175
UniProt	O43283 (UniProt - Evidence at protein level)
neXtProt	NX_O43283
Antibodypedia	MAP3K13 antibodies

PROTEIN BROWSER

MAP3K13-001	MAP3K13-003	MAP3K13-004	MAP3K13-005	MAP3K13-006	MAP3K13-010	MAP3K13-011	MAP3K13-012	MAP3K13-013	MAP3K13-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP3K13-001 ENSP00000265026 ENST00000265026	O43283 [Direct mapping] Mitogen-activated protein kinase kinase kinase 13 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations Show all	GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007254 [JNK cascade] GO:0008385 [IkappaB kinase complex] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	966 aa 108.3 kDa	No	0
MAP3K13-003 ENSP00000399910 ENST00000424227	O43283 [Direct mapping] Mitogen-activated protein kinase kinase kinase 13 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations Show all	GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007254 [JNK cascade] GO:0008385 [IkappaB kinase complex] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	966 aa 108.3 kDa	No	0
MAP3K13-004 ENSP00000411483 ENST00000446828	O43283 [Direct mapping] Mitogen-activated protein kinase kinase kinase 13 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations Show all	GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007254 [JNK cascade] GO:0008385 [IkappaB kinase complex] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	759 aa 85.4 kDa	No	0
MAP3K13-005 ENSP00000392223 ENST00000448876	C9IYH2 [Direct mapping] Mitogen-activated protein kinase kinase kinase 13 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations Show all		40 aa 4.6 kDa	No	0
MAP3K13-006 ENSP00000409325 ENST00000443863	O43283 [Direct mapping] Mitogen-activated protein kinase kinase kinase 13 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations Show all	GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007254 [JNK cascade] GO:0008385 [IkappaB kinase complex] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	822 aa 92.7 kDa	No	0
MAP3K13-010 ENSP00000389495 ENST00000447637	C9JP65 [Direct mapping] Mitogen-activated protein kinase kinase kinase 13 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations Show all		113 aa 12.4 kDa	No	0
MAP3K13-011 ENSP00000412037 ENST00000454237	C9IYH2 [Direct mapping] Mitogen-activated protein kinase kinase kinase 13 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations Show all		40 aa 4.6 kDa	No	0
MAP3K13-012 ENSP00000405163 ENST00000428617	C9J4W2 [Direct mapping] Mitogen-activated protein kinase kinase kinase 13 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations Show all	GO:0000186 [activation of MAPKK activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005622 [intracellular] GO:0007254 [JNK cascade] GO:0042803 [protein homodimerization activity] GO:0046777 [protein autophosphorylation] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	137 aa 14.8 kDa	No	0
MAP3K13-013 ENSP00000415712 ENST00000420577	H7C459 [Direct mapping] Mitogen-activated protein kinase kinase kinase 13 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations Show all	GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0007254 [JNK cascade] GO:0042803 [protein homodimerization activity] GO:0046777 [protein autophosphorylation] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] Show all	246 aa 28.6 kDa	No	0
MAP3K13-014 ENSP00000390323 ENST00000438798	C9IYH2 [Direct mapping] Mitogen-activated protein kinase kinase kinase 13 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations Show all		40 aa 4.6 kDa	No	0

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