We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Cytoplasmic expression in liver, prostate, distal renal tubules and lymphoid tissue.
ANTIBODY IHC RELIABILITY
Data reliability description
Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Paired antibodies with similar staining pattern support the protein profile.
Lymphomas and hepatocellular carcinomas along with several cases of testicular, prostate, ovarian and endometrial cancers showed moderate to strong cytoplasmic immunoreactivity. Remaining cancers were generally negative.
Most cases of non-Hodgkins lymphomas and hepatocellular carcinomas as well as a few cases of prostate cancer exhibited moderate to strong cytoplasmic immunoreactivity with additional membranous staining in several cases. Remaining tumors were mainly negative.
This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009]