Expression of ATP2A3 in cancer - Summary - The Human Protein Atlas

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ATP2A3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ATP2A3
Gene description	ATPase, Ca++ transporting, ubiquitous
Protein class	Enzymes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Daudi, HMC-1, MOLT-4, SK-BR-3)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA007180 , CAB010882
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable) and head and neck cancer (favourable).
Cervical cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007180	CAB010882

GENE INFORMATION
Gene name	ATP2A3 (HGNC Symbol)
Synonyms	SERCA3
Description	ATPase, Ca++ transporting, ubiquitous (HGNC Symbol)
Entrez gene summary	This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	3923870 - 3964464
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000074370 (version 83.38)
Entrez gene	489
UniProt	Q93084 (UniProt - Evidence at protein level)
neXtProt	NX_Q93084
Antibodypedia	ATP2A3 antibodies

PROTEIN BROWSER

ATP2A3-001	ATP2A3-002	ATP2A3-004	ATP2A3-005	ATP2A3-006	ATP2A3-007	ATP2A3-015	ATP2A3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP2A3-001 ENSP00000380234 ENST00000397041	Q93084 [Direct mapping] Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0031965 [nuclear membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	999 aa 109.3 kDa	No	>9
ATP2A3-002 ENSP00000380236 ENST00000397043	Q93084 [Direct mapping] Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0031965 [nuclear membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	998 aa 109.1 kDa	No	>9
ATP2A3-004 ENSP00000380229 ENST00000397035	Q93084 [Direct mapping] Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0031965 [nuclear membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	1029 aa 112.5 kDa	No	>9
ATP2A3-005 ENSP00000353072 ENST00000359983	Q93084 [Direct mapping] Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0031965 [nuclear membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	1052 aa 114.9 kDa	No	>9
ATP2A3-006 ENSP00000461480 ENST00000570845	A0A0C4DGN3 [Direct mapping] Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	153 aa 17.2 kDa	No	2
ATP2A3-007 ENSP00000458865 ENST00000572116	A0A0C4DGN1 [Direct mapping] Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	142 aa 15.8 kDa	No	2
ATP2A3-015 ENSP00000301387 ENST00000352011	Q93084 [Direct mapping] Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0031965 [nuclear membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	1043 aa 114 kDa	No	>9
ATP2A3-201 ENSP00000312577 ENST00000309890	Q93084 [Direct mapping] Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005388 [calcium-transporting ATPase activity] GO:0005524 [ATP binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016529 [sarcoplasmic reticulum] GO:0031095 [platelet dense tubular network membrane] GO:0031965 [nuclear membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034220 [ion transmembrane transport] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	1029 aa 112.5 kDa	No	>9

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