Expression of NTN4 in cancer - Summary - The Human Protein Atlas

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NTN4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NTN4
Gene description	Netrin 4
Protein class	Cancer-related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ hTERT+, PC-3, TIME)
HPA (normal tissue):	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA049832
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), urothelial cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049832

GENE INFORMATION
Gene name	NTN4
Synonyms
Description	Netrin 4 (HGNC Symbol)
Entrez gene summary	NTN4 belongs to a family of proteins related to laminins (see LAMA1, MIM 150320) Koch et al. (2000) [PubMed 11038171].[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q22
Chromosome location (bp)	95657807 - 95791152
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000074527 (version 83.38)
Entrez gene	59277
UniProt	Q9HB63 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HB63
Antibodypedia	NTN4 antibodies

PROTEIN BROWSER

NTN4-001	NTN4-002	NTN4-003	NTN4-004	NTN4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NTN4-001 ENSP00000340998 ENST00000343702	Q9HB63 [Direct mapping] Netrin-4 Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005604 [basement membrane] GO:0005886 [plasma membrane] GO:0007411 [axon guidance] GO:0016322 [neuron remodeling] GO:0030198 [extracellular matrix organization] GO:0043237 [laminin-1 binding] GO:0060668 [regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling] Show all	628 aa 70.1 kDa	Yes	0
NTN4-002 ENSP00000444432 ENST00000538383	Q9HB63 [Direct mapping] Netrin-4 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005604 [basement membrane] GO:0005886 [plasma membrane] GO:0007411 [axon guidance] GO:0030198 [extracellular matrix organization] Show all	591 aa 66.4 kDa	No	0
NTN4-003 ENSP00000339436 ENST00000344911	Q9HB63 [Direct mapping] Netrin-4 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005604 [basement membrane] GO:0005886 [plasma membrane] GO:0007411 [axon guidance] GO:0030198 [extracellular matrix organization] Show all	591 aa 66.4 kDa	No	0
NTN4-004 ENSP00000447292 ENST00000553059	Q9HB63 [Direct mapping] Netrin-4 Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005604 [basement membrane] GO:0005886 [plasma membrane] GO:0007411 [axon guidance] GO:0030198 [extracellular matrix organization] Show all	605 aa 67.5 kDa	Yes	0
NTN4-005 ENSP00000447594 ENST00000547980	F8W0I7 [Direct mapping] Netrin-4 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		176 aa 19.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.