Cell atlas - BCS1L - The Human Protein Atlas

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BCS1L

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	BCS1L
Gene description	BC1 (ubiquinol-cytochrome c reductase) synthesis-like
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA037701
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA037701	A-431	Vesicles
	HPA037701	U-2 OS	Vesicles
	HPA037701	U-251 MG	Vesicles

GENE INFORMATION
Gene name	BCS1L (HGNC Symbol)
Synonyms	BCS, BJS, h-BCS, Hs.6719
Description	BC1 (ubiquinol-cytochrome c reductase) synthesis-like (HGNC Symbol)
Entrez gene summary	This gene encodes a homolog of the S. cerevisiae bcs1 protein which is involved in the assembly of complex III of the mitochondrial respiratory chain. The encoded protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria. Mutations in this gene are associated with mitochondrial complex III deficiency and the GRACILE syndrome. Five alternatively spliced transcripts encoding the same protein have been described. [provided by RefSeq, Mar 2012]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	218658764 - 218663443
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000074582 (version 83.38)
Entrez gene	617
UniProt	Q9Y276 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y276
Antibodypedia	BCS1L antibodies

PROTEIN BROWSER

BCS1L-001	BCS1L-002	BCS1L-003	BCS1L-004	BCS1L-005	BCS1L-006	BCS1L-007	BCS1L-008	BCS1L-009	BCS1L-010	BCS1L-011	BCS1L-013	BCS1L-018	BCS1L-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCS1L-001 ENSP00000375957 ENST00000392109	Q9Y276 [Direct mapping] Mitochondrial chaperone BCS1 A0A024R467 [Target identity:100%; Query identity:100%] BCS1-like (Yeast), isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005750 [mitochondrial respiratory chain complex III] GO:0007005 [mitochondrion organization] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0033617 [mitochondrial respiratory chain complex IV assembly] GO:0034551 [mitochondrial respiratory chain complex III assembly] Show all	419 aa 47.5 kDa	No	1
BCS1L-002 ENSP00000375958 ENST00000392110	Q9Y276 [Direct mapping] Mitochondrial chaperone BCS1 A0A024R467 [Target identity:100%; Query identity:100%] BCS1-like (Yeast), isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005750 [mitochondrial respiratory chain complex III] GO:0007005 [mitochondrion organization] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0033617 [mitochondrial respiratory chain complex IV assembly] GO:0034551 [mitochondrial respiratory chain complex III assembly] Show all	419 aa 47.5 kDa	No	1
BCS1L-003 ENSP00000352219 ENST00000359273	Q9Y276 [Direct mapping] Mitochondrial chaperone BCS1 A0A024R467 [Target identity:100%; Query identity:100%] BCS1-like (Yeast), isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005750 [mitochondrial respiratory chain complex III] GO:0007005 [mitochondrion organization] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0033617 [mitochondrial respiratory chain complex IV assembly] GO:0034551 [mitochondrial respiratory chain complex III assembly] Show all	419 aa 47.5 kDa	No	1
BCS1L-004 ENSP00000406494 ENST00000412366	Q9Y276 [Direct mapping] Mitochondrial chaperone BCS1 A0A024R467 [Target identity:100%; Query identity:100%] BCS1-like (Yeast), isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005750 [mitochondrial respiratory chain complex III] GO:0007005 [mitochondrion organization] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0033617 [mitochondrial respiratory chain complex IV assembly] GO:0034551 [mitochondrial respiratory chain complex III assembly] Show all	419 aa 47.5 kDa	No	1
BCS1L-005 ENSP00000404999 ENST00000439945	Q9Y276 [Direct mapping] Mitochondrial chaperone BCS1 A0A024R467 [Target identity:100%; Query identity:100%] BCS1-like (Yeast), isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005750 [mitochondrial respiratory chain complex III] GO:0007005 [mitochondrion organization] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0033617 [mitochondrial respiratory chain complex IV assembly] GO:0034551 [mitochondrial respiratory chain complex III assembly] Show all	419 aa 47.5 kDa	No	1
BCS1L-006 ENSP00000413908 ENST00000431802	Q9Y276 [Direct mapping] Mitochondrial chaperone BCS1 A0A024R467 [Target identity:100%; Query identity:100%] BCS1-like (Yeast), isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005750 [mitochondrial respiratory chain complex III] GO:0007005 [mitochondrion organization] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0033617 [mitochondrial respiratory chain complex IV assembly] GO:0034551 [mitochondrial respiratory chain complex III assembly] Show all	419 aa 47.5 kDa	No	1
BCS1L-007 ENSP00000375959 ENST00000392111	Q9Y276 [Direct mapping] Mitochondrial chaperone BCS1 A0A024R467 [Target identity:100%; Query identity:100%] BCS1-like (Yeast), isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005750 [mitochondrial respiratory chain complex III] GO:0007005 [mitochondrion organization] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0033617 [mitochondrial respiratory chain complex IV assembly] GO:0034551 [mitochondrial respiratory chain complex III assembly] Show all	419 aa 47.5 kDa	No	1
BCS1L-008 ENSP00000391007 ENST00000428880	C9J4Q9 [Direct mapping] Mitochondrial chaperone BCS1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	77 aa 8.6 kDa	No	1
BCS1L-009 ENSP00000398957 ENST00000430322	C9J8G3 [Direct mapping] Mitochondrial chaperone BCS1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:0034551 [mitochondrial respiratory chain complex III assembly] Show all	206 aa 23.7 kDa	No	1
BCS1L-010 ENSP00000395440 ENST00000456050	C9J8G3 [Direct mapping] Mitochondrial chaperone BCS1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:0034551 [mitochondrial respiratory chain complex III assembly] Show all	206 aa 23.7 kDa	No	1
BCS1L-011 ENSP00000412729 ENST00000443791	C9J1S9 [Direct mapping] Mitochondrial chaperone BCS1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0034551 [mitochondrial respiratory chain complex III assembly] Show all	150 aa 17.1 kDa	No	0
BCS1L-013 ENSP00000397293 ENST00000423377	C9JAS4 [Direct mapping] Mitochondrial chaperone BCS1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:0034551 [mitochondrial respiratory chain complex III assembly] Show all	110 aa 12.5 kDa	No	1
BCS1L-018 ENSP00000416169 ENST00000426649	H7C492 [Direct mapping] Mitochondrial chaperone BCS1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0034551 [mitochondrial respiratory chain complex III assembly] Show all	201 aa 22.1 kDa	No	0
BCS1L-019 ENSP00000389402 ENST00000436603	H7BZF6 [Direct mapping] Mitochondrial chaperone BCS1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0034551 [mitochondrial respiratory chain complex III assembly] Show all	121 aa 13 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.