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NUAK1

GENERAL INFORMATION

Gene name

 NUAK1

Gene description

 NUAK family, SNF1-like kinase, 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, parathyroid gland)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (brain)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissue types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA027455
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain)

GENE INFORMATION

Gene name

 NUAK1 (HGNC Symbol)

Synonyms

 ARK5, KIAA0537, NuaK1

Description

 NUAK family, SNF1-like kinase, 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 12

Cytoband

 q23.3

Chromosome location (bp)

 106063340 - 106140033

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000074590 (version 83.38)

Entrez gene

 9891

UniProt

 O60285 (UniProt - Evidence at protein level)

neXtProt

 NX_O60285

Antibodypedia

 NUAK1 antibodies

PROTEIN BROWSER
NUAK1-001
NUAK1-003
NUAK1-004
NUAK1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUAK1-001
ENSP00000261402
ENST00000261402
O60285 [Direct mapping]
NUAK family SNF1-like kinase 1
A0A024RBL3 [Target identity:100%; Query identity:100%]
NUAK family, SNF1-like kinase, 1, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007155 [cell adhesion]
GO:0015630 [microtubule cytoskeleton]
GO:0030155 [regulation of cell adhesion]
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0032007 [negative regulation of TOR signaling]
GO:0035507 [regulation of myosin-light-chain-phosphatase activity]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042149 [cellular response to glucose starvation]
GO:0046872 [metal ion binding]
GO:2000772 [regulation of cellular senescence]
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 661 aa
74.3 kDa 		No 0
NUAK1-003
ENSP00000446873
ENST00000553094
F8VZ96 [Direct mapping]
NUAK family SNF1-like kinase 1
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Predicted intracellular proteins
Show all
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0032007 [negative regulation of TOR signaling]
GO:0035556 [intracellular signal transduction]
GO:0042149 [cellular response to glucose starvation]
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 118 aa
13.4 kDa 		No 0
NUAK1-004
ENSP00000448288
ENST00000548902
F8VSH4 [Direct mapping]
NUAK family SNF1-like kinase 1
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   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0032007 [negative regulation of TOR signaling]
GO:0035556 [intracellular signal transduction]
GO:0042149 [cellular response to glucose starvation]
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 152 aa
17.6 kDa 		No 0
NUAK1-005
ENSP00000449990
ENST00000549704
F8VXF0 [Direct mapping]
NUAK family SNF1-like kinase 1
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Predicted intracellular proteins
Show all
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0032007 [negative regulation of TOR signaling]
GO:0035556 [intracellular signal transduction]
GO:0042149 [cellular response to glucose starvation]
Show all
 74 aa
8.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.