Expression of DPP8 in cancer - Summary - The Human Protein Atlas

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DPP8

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DPP8
Gene description	Dipeptidyl-peptidase 8
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA008706
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008706

GENE INFORMATION
Gene name	DPP8 (HGNC Symbol)
Synonyms	DP8, DPRP1, FLJ14920, FLJ20283, MGC26191, MSTP141
Description	Dipeptidyl-peptidase 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q22.31
Chromosome location (bp)	65442463 - 65517704
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000074603 (version 83.38)
Entrez gene	54878
UniProt	Q6V1X1 (UniProt - Evidence at protein level)
neXtProt	NX_Q6V1X1
Antibodypedia	DPP8 antibodies

PROTEIN BROWSER

DPP8-001	DPP8-002	DPP8-003	DPP8-004	DPP8-007	DPP8-011	DPP8-012	DPP8-014	DPP8-015	DPP8-016	DPP8-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPP8-001 ENSP00000339208 ENST00000341861	Q6V1X1 [Direct mapping] Dipeptidyl peptidase 8 A0A024R5Z6 [Target identity:100%; Query identity:100%] Dipeptidyl-peptidase 8, isoform CRA_f Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006955 [immune response] GO:0008236 [serine-type peptidase activity] GO:0008239 [dipeptidyl-peptidase activity] Show all	898 aa 103.4 kDa	No	0
DPP8-002 ENSP00000318111 ENST00000321147	Q6V1X1 [Direct mapping] Dipeptidyl peptidase 8 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006955 [immune response] GO:0008236 [serine-type peptidase activity] GO:0008239 [dipeptidyl-peptidase activity] Show all	847 aa 97.5 kDa	No	0
DPP8-003 ENSP00000351817 ENST00000358939	Q6V1X1 [Direct mapping] Dipeptidyl peptidase 8 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases TMHMM predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006955 [immune response] GO:0008236 [serine-type peptidase activity] GO:0008239 [dipeptidyl-peptidase activity] Show all	782 aa 89.9 kDa	No	0
DPP8-004 ENSP00000300141 ENST00000300141	Q6V1X1 [Direct mapping] Dipeptidyl peptidase 8 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006955 [immune response] GO:0008236 [serine-type peptidase activity] GO:0008239 [dipeptidyl-peptidase activity] Show all	882 aa 101.4 kDa	No	0
DPP8-007 ENSP00000452643 ENST00000558559	H0YK36 [Direct mapping] Dipeptidyl peptidase 8 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	361 aa 41.1 kDa	No	0
DPP8-011 ENSP00000453954 ENST00000559233	Q6V1X1 [Direct mapping] Dipeptidyl peptidase 8 A0A024R5Z6 [Target identity:100%; Query identity:100%] Dipeptidyl-peptidase 8, isoform CRA_f Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006955 [immune response] GO:0008236 [serine-type peptidase activity] GO:0008239 [dipeptidyl-peptidase activity] Show all	898 aa 103.4 kDa	No	0
DPP8-012 ENSP00000453870 ENST00000560436	H0YN53 [Direct mapping] Dipeptidyl peptidase 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	120 aa 14.2 kDa	No	0
DPP8-014 ENSP00000453756 ENST00000560665	H0YMV1 [Direct mapping] Dipeptidyl peptidase 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		84 aa 9.9 kDa	No	0
DPP8-015 ENSP00000452719 ENST00000558529	H0YKA2 [Direct mapping] Dipeptidyl peptidase 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	219 aa 25.1 kDa	No	0
DPP8-016 ENSP00000455592 ENST00000559526	H3BQ40 [Direct mapping] Dipeptidyl peptidase 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] Show all	162 aa 18.9 kDa	No	0
DPP8-020 ENSP00000454922 ENST00000558786	H3BNM2 [Direct mapping] Dipeptidyl peptidase 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	311 aa 35.4 kDa	No	0

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