Expression of ZZEF1 in cancer - Summary - The Human Protein Atlas

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ZZEF1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZZEF1
Gene description	Zinc finger, ZZ-type with EF-hand domain 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA031778 , HPA031790
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable) and pancreatic cancer (favourable).
Head and neck cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031778	HPA031790

GENE INFORMATION
Gene name	ZZEF1 (HGNC Symbol)
Synonyms	FLJ10821, KIAA0399, ZZZ4
Description	Zinc finger, ZZ-type with EF-hand domain 1 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	4004445 - 4143020
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000074755 (version 83.38)
Entrez gene	23140
UniProt	O43149 (UniProt - Evidence at protein level)
neXtProt	NX_O43149
Antibodypedia	ZZEF1 antibodies

PROTEIN BROWSER

ZZEF1-001	ZZEF1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZZEF1-001 ENSP00000371051 ENST00000381638	O43149 [Direct mapping] Zinc finger ZZ-type and EF-hand domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0008270 [zinc ion binding] Show all	2961 aa 331.1 kDa	No	2
ZZEF1-005 ENSP00000458554 ENST00000573183	I3L141 [Direct mapping] Zinc finger ZZ-type and EF-hand domain-containing protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	812 aa 90.5 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.