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ENO1

GENERAL INFORMATION

Gene name

 ENO1

Gene description

 Enolase 1, (alpha)

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
CAB018614 , CAB069394
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and glioma (unfavourable).
Liver cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY
CAB018614
CAB069394

GENE INFORMATION

Gene name

 ENO1 (HGNC Symbol)

Synonyms

 ENO1L1, MBP-1, MPB1, PPH

Description

 Enolase 1, (alpha) (HGNC Symbol)

Entrez gene summary

 This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]

Chromosome

 1

Cytoband

 p36.23

Chromosome location (bp)

 8861002 - 8879249

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000074800 (version 83.38)

Entrez gene

 2023

UniProt

 P06733 (UniProt - Evidence at protein level)

neXtProt

 NX_P06733

Antibodypedia

 ENO1 antibodies

PROTEIN BROWSER
ENO1-001
ENO1-004
ENO1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENO1-001
ENSP00000234590
ENST00000234590
P06733 [Direct mapping]
Alpha-enolase
A0A024R4F1 [Target identity:100%; Query identity:100%]
Enolase 1, (Alpha), isoform CRA_a
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Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000287 [magnesium ion binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006351 [transcription, DNA-templated]
GO:0009615 [response to virus]
GO:0016020 [membrane]
GO:0030308 [negative regulation of cell growth]
GO:0031430 [M band]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051020 [GTPase binding]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
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 434 aa
47.2 kDa 		No 0
ENO1-004
ENSP00000466406
ENST00000497492
K7EM90 [Direct mapping]
Enolase
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0006096 [glycolytic process]
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 195 aa
21 kDa 		No 0
ENO1-008
ENSP00000468392
ENST00000489867
K7ERS8 [Direct mapping]
Alpha-enolase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 18 aa
2.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.