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Most cancer tissues showed weak to moderate cytoplasmic positivity. A few colorectal cancers showed strong staining. Most lymphomas, gliomas, skin and testicular cancers along with several cervical and urothelial cancers were negative.
Most cancer tissues showed weak to moderate cytoplasmic positivity. A few cases of hepatocellular carcinomas exhibited strong immunoreactivity. Lymphomas, gliomas and testicular cancers along with several ovarian cancers were negative.
The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]