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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ANO8
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ANO8

Gene description

Anoctamin 8

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining not consistent with RNA expression data. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA049206
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY

HPA049206

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Fraction of cells in a few cases of malignant melanomas, malignant gliomas and urothelial cancers displayed moderate to strong nuclear and/or occasional cytoplasmic immunoreactivity. Remaining cancers tissues were generally negative.

GENE INFORMATION

Gene name

ANO8 (HGNC Symbol)

Synonyms

KIAA1623, TMEM16H

Description

Anoctamin 8 (HGNC Symbol)

Entrez gene summary

Chromosome

19

Cytoband

p13.11

Chromosome location (bp)

17323223 - 17334829

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000074855 (version 83.38)

Entrez gene

57719

UniProt

Q9HCE9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HCE9

Antibodypedia

ANO8 antibodies

PROTEIN BROWSER

ANO8-001
ANO8-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ANO8-001
ENSP00000159087
ENST00000159087
Q9HCE9 [Direct mapping]
Anoctamin-8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006821 [chloride transport]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
1232 aa
136 kDa
No 8
ANO8-201
ENSP00000486865
ENST00000630631
M0QYD2 [Direct mapping]
Anoctamin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0016021 [integral component of membrane]
Show all
581 aa
65.6 kDa
No 5

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