Fields »
ABOUT
HELP
BLOG
TUBE1

GENERAL INFORMATION

Gene name

 TUBE1

Gene description

 Tubulin, epsilon 1

Protein class

 FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in a majority of tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA032073 , HPA032074
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA032073
HPA032074

GENE INFORMATION

Gene name

 TUBE1 (HGNC Symbol)

Synonyms

 dJ142L7.2, FLJ22589, TUBE

Description

 Tubulin, epsilon 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]

Chromosome

 6

Cytoband

 q21

Chromosome location (bp)

 112070777 - 112087529

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000074935 (version 83.38)

Entrez gene

 51175

UniProt

 Q9UJT0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UJT0

Antibodypedia

 TUBE1 antibodies

PROTEIN BROWSER
TUBE1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBE1-001
ENSP00000357651
ENST00000368662
Q9UJT0 [Direct mapping]
Tubulin epsilon chain
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000242 [pericentriolar material]
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0007098 [centrosome cycle]
GO:0008152 [metabolic process]
GO:0043234 [protein complex]
GO:0051258 [protein polymerization]
Show all
 475 aa
52.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.