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ARHGEF10L

GENERAL INFORMATION

Gene name

 ARHGEF10L

Gene description

 Rho guanine nucleotide exchange factor (GEF) 10-like

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA026426 , HPA026440 , HPA028115
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable) and renal cancer (favourable).
Head and neck cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026426
HPA026440
HPA028115

GENE INFORMATION

Gene name

 ARHGEF10L (HGNC Symbol)

Synonyms

 FLJ10521, KIAA1626

Description

 Rho guanine nucleotide exchange factor (GEF) 10-like (HGNC Symbol)

Entrez gene summary

 ARHGEF10L is a member of the RhoGEF family of guanine nucleotide exchange factors (GEFs) that activate Rho GTPases (Winkler et al., 2005 [PubMed 16112081]).[supplied by OMIM, Dec 2008]

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 17539835 - 17697874

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000074964 (version 83.38)

Entrez gene

 55160

UniProt

 Q9HCE6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HCE6

Antibodypedia

 ARHGEF10L antibodies

PROTEIN BROWSER
ARHGEF10L-001
ARHGEF10L-002
ARHGEF10L-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF10L-001
ENSP00000355060
ENST00000361221
Q9HCE6 [Direct mapping]
Rho guanine nucleotide exchange factor 10-like protein
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 1279 aa
140.4 kDa 		No 0
ARHGEF10L-002
ENSP00000364557
ENST00000375408
Q5VXI4 [Direct mapping]
Rho guanine nucleotide exchange factor 10-like protein
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0032933 [SREBP signaling pathway]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0051496 [positive regulation of stress fiber assembly]
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 1052 aa
115.6 kDa 		No 0
ARHGEF10L-003
ENSP00000364564
ENST00000375415
Q9HCE6 [Direct mapping]
Rho guanine nucleotide exchange factor 10-like protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 1240 aa
135.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.