Expression of KCNQ2 in cancer - Summary - The Human Protein Atlas

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KCNQ2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KCNQ2
Gene description	Potassium channel, voltage gated KQT-like subfamily Q, member 2
Protein class	Disease related genes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enhanced (AN3-CA, SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly expressed in the CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Sub cellular location is contradicted by external data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA016642 , HPA057112
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016642	HPA057112

GENE INFORMATION
Gene name	KCNQ2 (HGNC Symbol)
Synonyms	BFNC, EBN, EBN1, ENB1, HNSPC, KCNA11, Kv7.2
Description	Potassium channel, voltage gated KQT-like subfamily Q, member 2 (HGNC Symbol)
Entrez gene summary	The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	63400210 - 63472677
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000075043 (version 83.38)
Entrez gene	3785
UniProt	O43526 (UniProt - Evidence at protein level)
neXtProt	NX_O43526
Antibodypedia	KCNQ2 antibodies

PROTEIN BROWSER

KCNQ2-001	KCNQ2-002	KCNQ2-003	KCNQ2-004	KCNQ2-005	KCNQ2-006	KCNQ2-007	KCNQ2-011	KCNQ2-012	KCNQ2-013	KCNQ2-018	KCNQ2-019	KCNQ2-020	KCNQ2-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNQ2-001 ENSP00000486706 ENST00000626839	O43526 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030506 [ankyrin binding] GO:0033268 [node of Ranvier] GO:0034765 [regulation of ion transmembrane transport] GO:0043194 [axon initial segment] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	854 aa 94.1 kDa	No	5
KCNQ2-002 ENSP00000486194 ENST00000629676	A0A0D9SF10 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	645 aa 71.2 kDa	No	6
KCNQ2-003 ENSP00000352035 ENST00000359125	O43526 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0008076 [voltage-gated potassium channel complex] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019226 [transmission of nerve impulse] GO:0030506 [ankyrin binding] GO:0033268 [node of Ranvier] GO:0034765 [regulation of ion transmembrane transport] GO:0043194 [axon initial segment] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	872 aa 95.8 kDa	No	6
KCNQ2-004 ENSP00000486040 ENST00000625514	A0A0D9SEV1 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	754 aa 83.4 kDa	No	5
KCNQ2-005 ENSP00000487142 ENST00000629241	A0A0D9SG49 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	730 aa 80.8 kDa	No	6
KCNQ2-006 ENSP00000345523 ENST00000344425	O43526 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 2 Q53Y30 [Target identity:100%; Query identity:100%] Potassium voltage-gated channel, KQT-like subfamily, member 2; Potassium voltage-gated channel, KQT-like subfamily, member 2, isoform CRA_e Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030506 [ankyrin binding] GO:0033268 [node of Ranvier] GO:0034765 [regulation of ion transmembrane transport] GO:0043194 [axon initial segment] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	393 aa 44.3 kDa	No	6
KCNQ2-007 ENSP00000359244 ENST00000370224	Q4VXP6 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	766 aa 84.8 kDa	No	5
KCNQ2-011 ENSP00000353668 ENST00000360480	O43526 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030506 [ankyrin binding] GO:0033268 [node of Ranvier] GO:0034765 [regulation of ion transmembrane transport] GO:0043194 [axon initial segment] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	844 aa 93.1 kDa	No	6
KCNQ2-012 ENSP00000339611 ENST00000344462	O43526 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0007268 [synaptic transmission] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030506 [ankyrin binding] GO:0033268 [node of Ranvier] GO:0034765 [regulation of ion transmembrane transport] GO:0043194 [axon initial segment] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	841 aa 92.6 kDa	No	5
KCNQ2-013 ENSP00000349789 ENST00000357249	A0A0G2JH35 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0005267 [potassium channel activity] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	728 aa 80.5 kDa	No	4
KCNQ2-018 ENSP00000486509 ENST00000629498	A0A0D9SFE0 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005251 [delayed rectifier potassium channel activity] GO:0006811 [ion transport] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	153 aa 17 kDa	No	1
KCNQ2-019 ENSP00000487563 ENST00000626684	A0A0D9SGJ7 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005251 [delayed rectifier potassium channel activity] GO:0008076 [voltage-gated potassium channel complex] GO:0016021 [integral component of membrane] GO:0071805 [potassium ion transmembrane transport] Show all	192 aa 21.4 kDa	No	3
KCNQ2-020 ENSP00000487469 ENST00000627221	A0A0D9SGG3 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0005251 [delayed rectifier potassium channel activity] GO:0008076 [voltage-gated potassium channel complex] GO:0016021 [integral component of membrane] GO:0071805 [potassium ion transmembrane transport] Show all	229 aa 25.3 kDa	No	0
KCNQ2-021 ENSP00000487384 ENST00000629318	A0A0D9SGD4 [Direct mapping] Potassium voltage-gated channel subfamily KQT member 2 Show all	Predicted intracellular proteins Show all	GO:0005251 [delayed rectifier potassium channel activity] GO:0008076 [voltage-gated potassium channel complex] GO:0016021 [integral component of membrane] GO:0071805 [potassium ion transmembrane transport] Show all	179 aa 19.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.