Expression of ACTR6 in cancer - Summary - The Human Protein Atlas

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ACTR6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACTR6
Gene description	ARP6 actin-related protein 6 homolog (yeast)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tisssues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA038587 , HPA038588
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038587	HPA038588

GENE INFORMATION
Gene name	ACTR6 (HGNC Symbol)
Synonyms	ARP6, FLJ13433
Description	ARP6 actin-related protein 6 homolog (yeast) (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q23.1
Chromosome location (bp)	100199122 - 100241865
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000075089 (version 83.38)
Entrez gene	64431
UniProt	Q9GZN1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9GZN1
Antibodypedia	ACTR6 antibodies

PROTEIN BROWSER

ACTR6-001	ACTR6-003	ACTR6-004	ACTR6-005	ACTR6-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACTR6-001 ENSP00000188312 ENST00000188312	Q9GZN1 [Direct mapping] Actin-related protein 6 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006281 [DNA repair] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0031011 [Ino80 complex] GO:0035267 [NuA4 histone acetyltransferase complex] Show all	396 aa 45.8 kDa	No	0
ACTR6-003 ENSP00000448669 ENST00000546902	G3V1Y1 [Direct mapping] ARP6 actin-related protein 6 homolog (Yeast), isoform CRA_d; Actin-related protein 6 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006281 [DNA repair] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0031011 [Ino80 complex] GO:0035267 [NuA4 histone acetyltransferase complex] Show all	314 aa 36.3 kDa	No	0
ACTR6-004 ENSP00000448356 ENST00000551617	F8VSD1 [Direct mapping] Actin-related protein 6 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006281 [DNA repair] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0031011 [Ino80 complex] GO:0035267 [NuA4 histone acetyltransferase complex] Show all	294 aa 34.1 kDa	No	0
ACTR6-005 ENSP00000447237 ENST00000552376	F8W057 [Direct mapping] Actin-related protein 6 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006281 [DNA repair] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0031011 [Ino80 complex] GO:0035267 [NuA4 histone acetyltransferase complex] Show all	376 aa 43.6 kDa	No	0
ACTR6-013 ENSP00000448508 ENST00000551652	F8VRL1 [Direct mapping] Actin-related protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006281 [DNA repair] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0031011 [Ino80 complex] GO:0035267 [NuA4 histone acetyltransferase complex] Show all	192 aa 22.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.